Prof Saskia Hogenhout
Cell and Developmental Biology
Research in the Hogenhout lab centres on Molecular-Plant-Microbe-Insect Interactions (MPMII).
Our first goal is to better understand the molecular basis of plant interactions with insect herbivores, particularly aphids, leafhoppers and whiteflies (hemipterans). These insects produce virulence proteins (effectors) in their saliva that modulate plant responses and aid insect colonization. We have identified insect effectors and are in the process of analysing their functions by finding plant targets and knocking down corresponding genes in the insects by plant-mediated RNA interference (RNAi).
Hemipteran insects are efficient transmitters of a diverse range of plant pathogens, predominantly viruses and bacteria, and hence may be viewed as the ‘mosquitoes of plants’. Therefore, our second goal is to understand plant-insect-pathogen interactions. Leafhoppers transmit phytoplasmas, which are bacterial plant pathogens related to mycoplasmas. Phytoplasmas induce dramatic changes in plant development, including proliferation of stems (witch’s brooms) and the reversion of flowers into leaf-like organs (phyllody). We have identified phytoplasma effectors that induce these phenotypes by interacting and degrading conserved proteins, including TCPs and MADS-box transcription factors. Plants also become very susceptible and attractive to insect vectors on which the phytoplasmas depend for transmission to other plants. Thus, phytoplasmas appear to completely hijack their plant hosts changing them into ‘zombies’ destined to maximise pathogen survival.
By definition, studies on MPMII are interdisciplinary and require expertise with at least three unrelated organisms. We work in close collaboration with Dr Ian Bedford and the Entomology facility at the John Innes Centre.
Publisher’s version: 10.1007/978-3-319-24049-7
Current Opinion in Insect Science 9 p16-23
Publisher’s version: 10.1016/j.cois.2015.04.007
Journal of Experimental Botany 66 (2) p541-8
Publisher’s version: 10.1093/jxb/eru450
Complete Genome Sequence of "Candidatus Sulcia muelleri" ML, an Obligate Nutritional Symbiont of Maize Leafhopper (Dalbulus maidis).
Genome announcements 3 pe01483-14
Publisher’s version: 10.1128/genomeA.01483-14
Metabolic regulation of phytoplasma malic enzyme and phosphotransacetylase supports the use of malate as an energy source in these plant pathogens.
Microbiology 160 p2794-806
Publisher’s version: 10.1099/mic.0.083469-0
- Friederike Bernsdorff Postdoctoral Scientist
- Christine Wilson Postgraduate Student
- Dr Vera Thole Postdoctoral Scientist
- Pascal Pecher Postdoctoral Scientist
- Zigmunds Orlovskis Postgraduate Student
- Dr Sam Mugford Research Assistant
- Claire Drurey Postgraduate Student
- Dr Yazhou Chen Postdoctoral Scientist
- Dr Ian Bedford Senior Scientist
- Thomas Vincent Postgraduate Student
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