Martin Howard publications

68. J. Hepworth, R. Antoniou-Kourounioti, R. Bloomer, C. Selga, K. Berggren, D. Cox, B. Collier Harris, J. Irwin, S. Holm, T. Säll, M. Howard and C. Dean:
Absence of warmth permits epigenetic memory of winter in Arabidopsis
Nature Commun. 9 639 (2018)

67. S. Berry, S. Rosa, M. Howard, M. Bühler and C. Dean:
Disruption of an RNA-binding hinge region abolishes LHP1-mediated epigenetic repression
Genes and Dev. 31 2115-2120 (2017)

66. G. Facchetti, F. Chang and M. Howard:
Controlling cell size through sizer mechanisms
Curr. Opin. Sys. Biol. 5 86-92 (2017)

65. H. Yang, S. Berry, T. Olsson, M. Hartley, M. Howard and C. Dean:
Distinct phases of Polycomb silencing to hold epigenetic memory of cold in Arabidopsis
Science 357 1142-1145 (2017)

64. R. Ietswaart, S. Rosa, Z. Wu, C. Dean and M. Howard:
Cell-Size-Dependent Transcription of FLC and Its Antisense Long Non-coding RNA COOLAIR Explain Cell-to-Cell Expression Variation
Cell Systems 4 622-635 (2017) - pdf file 

63. S. Berry, C. Dean and M. Howard:
Slow chromatin dynamics allow Polycomb target genes to filter fluctuations in transcription factor activity
Cell Systems 4 445–457 (2017) - pdf file 
Reviewed in Cell Systems Preview: "Reconciling Epigenetic Memory and Transcriptional Responsiveness"

62. R. Antoniou-Kourounioti and M. Howard:
Quantitative environmentally triggered switching between stable epigenetic states
Chap. 8 p. 169-187 in "Epigenetics and Systems Biology" (2017), ed. L. Ringrose

61. L. Ringrose and M. Howard:
Dissecting chromatin-mediated gene regulation and epigenetic memory through mathematical modelling
Curr. Opin. Sys. Biol. 3 7-14 (2017)

60. H. Yang, M. Howard and C. Dean:
Physical coupling of activation and derepression activities to maintain an active transcriptional state at FLC
Proc. Natl. Acad. Sci. 113 9369-9374 (2016)

59. Z. Wu, R. Ietswaart, F. Liu, H. Yang, M. Howard and C. Dean:
Quantitative regulation of FLC via coordinated transcriptional initiation and elongation
Proc. Natl. Acad. Sci. 113 218-223 (2016)

58. S. Berry, M. Hartley, T. Olsson, C. Dean and M. Howard:
Local chromatin environment of a Polycomb target gene instructs its own epigenetic inheritance
eLife 4 e07205 (2015) - pdf file

57. A. Angel, J. Song, H. Yang, J. Questa, C. Dean and M. Howard:
Vernalizing cold is registered digitally at FLC
Proc. Natl. Acad. Sci. 112 4146-4151 (2015)

56. A. Scialdone and M. Howard:
How plants manage food reserves at night: quantitative models and open questions
Front. Plant Sci. 6 204 (2015) - pdf file

55. R. Ietswaart, F. Szardenings, K. Gerdes and M. Howard:
Competing ParA Structures Space Bacterial Plasmids Equally over the Nucleoid
PLoS Comput. Biol. 10 e1004009 (2014) - pdf file , Supporting information pdf file

54. H. Yang, M. Howard and C. Dean:
Antagonistic Roles for H3K36me3 and H3K27me3 in the Cold-Induced Epigenetic Switch at Arabidopsis FLC
Curr. Biol. 24 1793-1797 (2014) - pdf file

53. K. Pan, T. Saunders, I. Flor-Parra, M. Howard and F. Chang:
Cortical regulation of cell size by a sizer cdr2p
eLife 3 e02040 (2014) - pdf file

52. S. Murray, G. Panis, C. Fumeaux, P. Viollier and M. Howard:
Computational and Genetic Reduction of a Cell Cycle to Its Simplest, Primordial Components
PLoS Biology 11 e1001749 (2013) - pdf file Supporting information pdf file
Reviewed in PLoS Biology synopsis: "Notes from the Cell Cycle World: Less Is More"

51. A. Scialdone, S. Mugford, D. Feike, A. Skeffington, P. Borrill, A. Graf, A. Smith and M. Howard:
Arabidopsis plants perform arithmetic division to prevent starvation at night
eLife 2 e00669 (2013) - pdf file

50. D. Richards, S. Berry and M. Howard:
Illustrations of Mathematical Modeling in Biology: Epigenetics, Meiosis, and an Outlook
Cold Spring Harb. Symp. Quant. Biol. 77 175-181 (2012) - pdf file

49. D. Richards, E. Greer, A. Martin, G. Moore, P. Shaw and M. Howard:
Quantitative Dynamics of Telomere Bouquet Formation
PLoS Comput. Biol. 8 e1002812 (2012) - pdf file , Supporting information pdf file

48. K. Flardh, D. Richards, A. Hempel, M. Howard and M. Buttner:
Regulation of apical growth and hyphal branching in Streptomyces
Curr. Opin. Microbiol. 15 737-743 (2012) - pdf file

47. J. Song, A. Angel, M. Howard and C. Dean:
Vernalization – a cold-induced epigenetic switch
J. Cell Sci. 125 3723-3731 (2012) - pdf file

46. M. Howard:
How to build a robust intracellular concentration gradient
Trends Cell Biol. 22 311-317 (2012) - pdf file
From the cover...

45. D. Richards, A. Hempel, K. Flardh, M. Buttner and M. Howard:
Mechanistic basis of branch-site selection in filamentous bacteria
PLoS Comput. Biol. 8 e1002423 (2012) - pdf file , Supporting information pdf file

44. T. Saunders, K. Pan, A. Angel, Y. Guan, J. Shah, M. Howard and F. Chang:
Noise Reduction in the Intracellular Pom1p Gradient by a Dynamic Clustering Mechanism
Dev. Cell 22 558-572 (2012) - pdf file, Supplemental information pdf file
Reviewed in Nature Rev. Genet. research highlight: "Development: Robust but responsive protein gradients"

43. A. Angel, J. Song, C. Dean and M. Howard:
A Polycomb-based switch underlying quantitative epigenetic memory
Nature 476 105-108 (2011) - pdf file, Supplementary information pdf file
Deutsche Welle news agencyFaculty of 1000

42. M. Howard and K. Gerdes:
What is the mechanism of ParA-mediated DNA movement?
Mol. Microbiol. 78 9-12 (2010) - pdf file

41. F. He, T. Saunders, Y. Wen, D. Cheung, R. Jiao, P.R. ten Wolde, M. Howard and J. Ma:
Shaping a morphogen gradient for positional precision
Biophys. J. 99 697-707 (2010)
pdf file, Supporting Material pdf file

40. K. Gerdes, M. Howard and F. Szardenings:
Pushing and pulling in prokaryotic DNA segregation
Cell 141 927-942 (2010) - pdf file

39. T. Erdmann, M. Howard and P.R. ten Wolde:
Role of spatial averaging in the precision of gene expression patterns
Phys. Rev. Lett. 103 258101 (2009) - pdf file

38. T. Saunders and M. Howard:
When it pays to rush: interpreting morphogen gradients prior to steady-state
Phys. Biol. 6 046020 (2009) - pdf file
Selected as a Highlight of 2009 by Physical Biology

37. S. Ringgaard, J. van Zon, M. Howard and K. Gerdes:
Movement and equipositioning of plasmids by ParA filament disassembly
Proc. Natl. Acad. Sci. 106 19369-19374 (2009) - pdf file , Supporting information pdf file
Recommended by Faculty of 1000

36. T. Saunders and M. Howard:
Morphogen profiles can be optimized to buffer against noise
Phys. Rev. E 80 041902 (2009) - pdf file 
Recommended by Faculty of 1000

35. J. van Zon, G. Tzircotis, E. Caron and M. Howard:
A mechanical bottleneck explains the variation in cup growth during FcγR phagocytosis
Mol. Syst. Biol. 5 298 (2009) - pdf file , Supporting Information pdf file

34. M. Howard:
Cell Division: Experiments and Modelling Unite to Resolve the Middle
Curr. Biol. 19 R67-R69 (2009) - pdf file

33. F. Tostevin and M. Howard:
Modeling the establishment of PAR protein polarity in the one-cell C. elegans embryo
Biophys. J. 95 4512-4522 (2008) - pdf file , Supporting Information pdf file 

32. F. Tostevin, P.R. ten Wolde and M. Howard:
Fundamental limits to position determination by concentration gradients
PLoS Comput. Biol. 3 e78 (2007) - pdf file 

31. K. Kruse, M. Howard and W. Margolin:
An experimentalist's guide to computational modelling of the Min system
Mol. Microbiol. 63 1279-1284 (2007) - pdf file 

30. N. Padte, S. Martin, M. Howard and F. Chang:
The cell-end factor Pom1p inhibits Mid1p in specification of the cell division plane in fission yeast
Curr. Biol. 16 2480-2487 (2006)
pdf file Supporting Information pdf file 
Reviewed in J. Cell Biol. research roundup: "Pom1p Prevents a Spreading Middle"
Reviewed in Curr. Biol. dispatch: "Cell Division: Mid-Level Management"

29. R. Sear and M. Howard:
Modeling dual pathways for the metazoan spindle assembly checkpoint
Proc. Natl. Acad. Sci. 103 16758-16763 (2006) - pdf file 

28. M. Howard:
Cell signalling: changing shape changes the signal
Curr. Biol. 16 R673-R675 (2006) - pdf file

27. F. Tostevin and M. Howard:
A stochastic model of Min oscillations in Escherichia coli and Min protein segregation during cell division
Phys. Biol. 3 1-12 (2006) - pdf file 
Selected as a Highlight of 2006 by Physical Biology

26. M. Howard and P.R. ten Wolde:
Finding the center reliably: robust patterns of developmental gene expression
Phys. Rev. Lett. 95 208103 (2005) - pdf file 

25. K. Doubrovinski and M. Howard:
Stochastic model for Soj relocation dynamics in Bacillus subtilis
Proc. Natl. Acad. Sci. 102 9808-9813 (2005) - pdf file , Supporting information pdf file 

24. U. Täuber, M. Howard and B. Vollmayr-Lee:
Applications of field-theoretic renormalization group methods to reaction-diffusion problems
J. Phys. A 38 R79-R131 (2005) - pdf file

23. M. Howard and K. Kruse:
Cellular organization by self-organization: mechanisms and models for Min protein dynamics
J. Cell Biol. 168 533-536 (2005) - pdf file 

22. C. Baggio, M. Howard and W. van Saarloos:
Dynamics and stability of vortex-antivortex fronts in type II superconductors
Phys. Rev. E. 70 026209 (2004) - pdf file

21. M. Howard:
A mechanism for polar protein localization in bacteria
J. Mol. Biol. 335 655-663 (2004) - pdf file

20. M. Howard and M. van Hecke:
Hole-defect chaos in the one-dimensional complex Ginzburg-Landau equation
Phys. Rev. E. 68 026213 (2003) - pdf file

19. M. Howard and A. Rutenberg:
Pattern formation inside bacteria: fluctuations due to the low copy number of proteins
Phys. Rev. Lett. 90 128102 (2003) - pdf file

18. M. Howard, A. Rutenberg and S. de Vet:
Dynamic compartmentalization of bacteria: accurate division in E. coli
Phys. Rev. Lett. 87 278102 (2001) - pdf file 
Reviewed at Nature news: "Sloshing proteins help bacteria find their waists"

17. M. van Hecke and M. Howard:
Ordered and self-disordered dynamics of holes and defects in the one-dimensional complex Ginzburg-Landau equation
Phys. Rev. Lett. 86 2018-2021 (2001) - pdf file 

16. D. Vernon and M. Howard:
Branching and annihilating Lévy flights
Phys. Rev. E 63 0411161-0411168 (2001) - pdf file

15. P. Fröjdh, M. Howard and K. Lauritsen:
Directed percolation and other systems with absorbing states: impact of boundaries
Int. J. Mod. Phys. B 15 1761-1797 (2001) - pdf file

14. M. Howard and R. Zia:
Fluctuations and correlations in population models with age structure
Int. J. Mod. Phys. B 15 391-402 (2001) - pdf file

13. M. Howard, P. Fröjdh and K. Lauritsen:
Surface critical behavior in systems with nonequilibrium phase transitions
Phys. Rev. E 61 167-183 (2000) - pdf file

12. Y. Goldschmidt, H. Hinrichsen, M. Howard and U. Täuber:
Nonequilibrium critical behavior in unidirectionally coupled stochastic processes
Phys. Rev. E 59 6381-6408 (1999 - pdf file

11. H. Hinrichsen and M. Howard:
A model for anomalous directed percolation
Eur. Phys. J. B 7 635-643 (1999 - pdf file

10. U. Täuber, M. Howard and H. Hinrichsen:
Phys. Rev. Lett. 81 2179 (1998) - pdf file 

9. K. Lauritsen, P. Fröjdh and M. Howard:
Surface critical behavior in systems with absorbing states
Phys. Rev. Lett. 81 2104-2107 (1998) - pdf file

8. M. Howard and C. Godrèche:
Persistence in the voter model: continuum reaction-diffusion approach
J. Phys. A 31 L209-L215 (1998) - pdf file

7. U. Täuber, M. Howard and H. Hinrichsen:
Multicritical behavior in coupled directed percolation processes
Phys. Rev. Lett. 80 2165-2168 (1998) - pdf file

6. P. Fröjdh, M. Howard and K. Lauritsen:
Directed percolation with a wall or edge
J. Phys. A 31 2311-2320 (1998) pdf file

5. M. Howard and U. Täuber:
"Real" versus "imaginary" noise in diffusion limited reactions
J. Phys. A 30 7721-7731 (1997) - pdf file

4. M. Howard and G. Barkema:
Shear flows and segregation in the reaction A+B→Ø
Phys. Rev. E 53 5949-5956 (1996) - pdf file

3. M. Howard:
Fluctuation kinetics in a multispecies reaction-diffusion system
J. Phys. A 29 3437-3460 (1996) - pdf file

2. G. Barkema, M. Howard and J. Cardy:
The reaction-diffusion front for A+B→Ø in one dimension
Phys. Rev. E 53 R2017-R2020 (1996) - pdf file

1. M. Howard and J. Cardy:
Fluctuation effects and multiscaling of the reaction-diffusion front for A+B→Ø
J. Phys. A 28 3599-3621 (1995) - pdf file

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