Mark’s research focuses on plant/microbe interactions at the molecular and cellular level.
The Mark Banfield lab explores the structure and function of intracellular disease resistance proteins (NLRs) – plant receptors which detect non-self molecules released by pathogens on infection.
They also investigate how host-translocated pathogen effector proteins function to promote disease. Understanding the genetic and structural changes involved in plant/microbe interactions informs novel approaches to the challenge of breeding disease resistance in crops such as potato and rice.
The Banfield Lab benefits from close links with colleagues at The Sainsbury Laboratory on the Norwich Research Park.
De la Concepcion J. C., Franceschetti M., Maqbool A., Saitoh H., Terauchi R., Kamoun S., Banfield M. J. (2018)Polymorphic residues in rice NLRs expand binding and response to effectors of the blast pathogen.Nature plantsPublisher's version: 2055-0278
Maqbool A., Hughes R. K., Dagdas Y. F., Tregidgo N., Zess E., Belhaj K., Round A., Bozkurt T. O., Kamoun S., Banfield M. J. (2016)Structural basis of host Autophagy-related protein 8 (ATG8) binding by the Irish potato famine pathogen effector protein PexRD54.Journal of Biological Chemistry (291)Publisher's version: 0021-9258
Maqbool A., Saitoh H., Franceschetti M., Stevenson C., Uemura A., Kanzaki H., Kamoun S., Terauchi R., Banfield M. J. (2015)Structural basis of pathogen recognition by an integrated HMA domain in a plant NLR immune receptor.eLife (4)Publisher's version: 2050-084X