Prof Martin Howard
Computational and Systems Biology
The Howard group mathematically models biological systems at the cellular level, with a focus on understanding fundamental biological mechanisms.
Our approach is to construct simple models that can nevertheless make surprising and counter-intuitive predictions to be tested experimentally. The group's approach is highly interdisciplinary, and relies heavily on techniques from statistical physics as well as on close collaboration with experimental groups both at the John Innes Centre and elsewhere.
A particular focus of the group is on mechanistic understanding of epigenetic processes, particularly during vernalization, the acceleration of flowering induced by winter cold. This work is in collaboration with the Caroline Dean group at JIC. A second focus of the group is on the mechanistic basis of cell size control in fission yeast, in collaboration with the Fred Chang group at UCSF."
ContactTel: 01603 450892
Cause or Consequence? Scientists help to settle an epigenetic debateread more
How Plants Remember Winter, and Other Storiesread more
PLoS Computational Biology 10 p e1004009
Publisher’s version: 10.1371/journal.pcbi.1004009
Current Opinion in Systems Biology 3 p7-14
Publisher’s version: 10.1016/j.coisb.2017.02.003
Physical coupling of activation and derepression activities to maintain an active transcriptional state at FLC.
Proceedings of the National Academy of Sciences of the United States of America 113 p9369-74
Publisher’s version: 10.1073/pnas.1605733113
Proceedings of the National Academy of Sciences of the United States of America 113 p218-23
Publisher’s version: 10.1073/pnas.1518369112
eLife 4 pe07205
Publisher’s version: 10.7554/eLife.07205
Postdoctoral Researchers in DNA methylation dynamicsread more
- Dr Rea Antoniou-Kourounioti Postdoctoral Scientist
- Dr Giuseppe Facchetti Postdoctoral Scientist
Institute of Physics Tom Duke Lecture Prize, 2014
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