Prof Caroline Dean

Project Leader
Cell and Developmental Biology

Caroline’s research investigates the genetic control of vernalization within plants which influences the transition from vegetative to reproductive growth.

She is interested in understanding how temperature signals integrate within the regulatory networks which control plant reproduction.

Caroline’s research involves deciphering the role of epigenetics on expression of the floral repressor gene FLC, using Arabidopsis for her research work and translating this into other Brassicas. 

  •  The mechanisms and pathways for controlling flowering time through vernalisation
  •  Temperature regulation of flowering in Brassicas
  •  Epigenetic control of the floral repressor gene, FLC

 

March 2015 - BBSRC Excellence in Bioscience Award Lecture

Caroline Dean's research has focused on the timing of the transition to reproductive development in plants. The acceleration of flowering by prolonged cold is a classic epigenetic process called vernalization. The study of this and parallel genetic pathways has led them into the dissection of conserved chromatin silencing mechanisms involving non-coding RNAs.

Their recent work has focused on a mechanistic understanding of vernalization and on the pathways that determine a requirement for vernalization. These pathways converge on a gene that encodes a floral repressor called FLC.  They analyse how these pathways intersect during development, in different environmental conditions, and through microevolution.

This takes them into the analysis of what regulates reproductive strategy in plants, which forms part of the Genes in the Environment ISP Theme 3: understanding how temperature signals integrate into regulatory networks controlling development. They use Arabidopsis as a reference to establish the regulatory hierarchy and then translate their findings into other species, particularly Brassica species.

FLC regulation has become a paradigm for the dissection of how non-coding RNAs, particularly antisense transcripts, mediate chromatin regulation. This work is therefore central to the GEN ISP Theme 1 - which aims to understand how genomes are regulated. It is also providing important insight into evolutionary mechanisms, as modulation of FLC regulation is an important determinant of Arabidopsis adaptation.

Distinguished role model for women in science receives global award

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JIC scientists remove reliance on seasonality in new line of broccoli – potentially doubling crop production

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A step closer to understanding the ‘switch’ that triggers flowering in plants

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Professor Caroline Dean awarded the Darwin Medal by the Royal Society

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Recent Publications

Ietswaart R., Rosa S., Wu Z., Dean C., Howard M. (2017)

Cell-Size-Dependent Transcription of FLC and Its Antisense Long Non-coding RNA COOLAIR Explain Cell-to-Cell Expression Variation.

Cell Systems 4 p622-635

Publisher’s version: 10.1016/j.cels.2017.05.010

Duncan S., Olsson T. G., Hartley M., Dean C., Rosa S. (2017)

Single Molecule RNA FISH in Arabidopsis Root Cells

Bio-Protocol 7 pe2240

Publisher’s version: 10.21769/BioProtoc.2240

Rosa S., Duncan S., Dean C. (2016)

Mutually exclusive sense–antisense transcription at FLC facilitates environmentally induced gene repression

Nature Communications 7 p13031

Publisher’s version: 10.1038/ncomms13031

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Caroline Dean

Awards

Made Dame Commander of the British Empire - Queen's Birthday Honours List 2016

FEBS/EMBO Women in Science Award, 2015

Thomson Reuters Top 1% Highly Cited Researcher, 2014

BBSRC Anniversary Award for Excellence in Bioscience, 2014

Non-resident Faculty of the Salk Institute, 2012-18

Foreign Member US National Academy of Sciences, elected April 2008

German Leopoldina Academy, elected April 2008

Officer of the Order of the British Empire, 2004

Fellow of the Royal Society, elected 2004

Genetics Society Medal, 2002

Elected a European Molecular Biology Organisation Fellow, 1999

Media

For media enquiries, contact the John Innes Centre communications team 01603 450962, jic.communications@jic.ac.uk

 

March 2015 - BBSRC Excellence in Bioscience Award Lecture

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