Prof Mark Banfield
Head of Department
The Banfield Lab addresses fundamental questions in pathogen-host interactions at the molecular level. A long-standing interest of the group is the study of structure/function relationships in effector proteins from pathogens of mammals and plants. Effector proteins are molecules secreted from pathogens that either localize outside of or are translocated into host cells where they act to promote pathogen colonization.
We also study the host side of plant immunity, or how plants respond to pathogens. Through the use of biochemical, biophysical and structural studies, we form hypotheses that are then tested in more in vivo settings. Ultimately, in addition to making fundamental discoveries concerning mechanisms of pathogen virulence, many of our studies are aimed at engineering plants to better resist infection by pathogens, improving performance in agriculture with a reduced need for chemical interventions.
We also investigate the molecular basis of host cell adhesion mediated by internal thioester bonds, highly unusual protein cross-links we discovered in pili from gram-positive pathogens of mammals.
ContactTel: 01603 450742
Pseudomonas syringae type III effector HopAF1 suppresses plant immunity by targeting methionine recycling to block ethylene induction.
Proceedings of the National Academy of Sciences of the United States of America 113 pE3577E3586
Publisher’s version: 10.1073/pnas.1606322113
eLife 5 p10856
Publisher’s version: 10.7554/eLife.10856
Tomato I2 immune receptor can be engineered to confer partial resistance to the oomycete Phytophthora infestans in addition to the fungus Fusarium oxysporum.
Molecular Plant Microbe Interactions
Publisher’s version: 10.1094/MPMI-07-15-0147-R
Structural basis of pathogen recognition by an integrated HMA domain in a plant NLR immune receptor.
eLife 4 p08709
Publisher’s version: 10.7554/eLife.08709
eLife 4 pe06638
Publisher’s version: 10.7554/eLife.06638
- Dr Sebastian Eves-van Den Akker Visiting Worker
- Freya Varden Postgraduate Student
- Lennart Wirthmueller Postdoctoral Scientist
- Dr Miriam Walden Postdoctoral Scientist
- John Steele Postgraduate Student
- Dr Abbas Maqbool Postdoctoral Scientist
- Dr Richard Hughes Research Assistant
- Benjamin Hall Postgraduate Student
- Dr Marina Franceschetti Postdoctoral Scientist
- Bushra Azmat Visiting Worker
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