Dr Mark Banfield
The Banfield Lab addresses fundamental questions in pathogen-host interactions at the molecular level. A long-standing interest of the group is the study of structure/function relationships in effector proteins from pathogens of mammals and plants. Effector proteins are molecules secreted from pathogens that either localize outside of or are translocated into host cells where they act to promote pathogen colonization.
We also study the host side of plant immunity, or how plants respond to pathogens. Through the use of biochemical, biophysical and structural studies, we form hypotheses that are then tested in more in vivo settings. Ultimately, in addition to making fundamental discoveries concerning mechanisms of pathogen virulence, many of our studies are aimed at engineering plants to better resist infection by pathogens, improving performance in agriculture with a reduced need for chemical interventions.
We also investigate the molecular basis of host cell adhesion mediated by internal thioester bonds, highly unusual protein cross-links we discovered in pili from gram-positive pathogens of mammals.
ContactTel: 01603 450742
Publisher’s version: 10.7554/eLife.06638
Frontiers in Plant Science 6
Publisher’s version: 10.3389/fpls.2015.00134
Publisher’s version: 10.1111/tpj.12691
Cellular Microbiology 17 (1) p18-25
Publisher’s version: 10.1111/cmi.12385
Intramolecular isopeptide but not internal thioester bonds confer proteolytic and significant thermal stability to the S. pyogenes pilus adhesin Spy0125.
Proteins: Structure, Function and Bioinformatics 82 (3) p517-27
Publisher’s version: 10.1002/prot.24420
- Farhan Mitha Undergraduate Project Student
- Mark Elms Undergraduate Project Student
- Dr Sebastian Eves-van Den Akker Visiting Worker
- Freya Varden Postgraduate Student
- Lennart Wirthmueller Postdoctoral Scientist
- Dr Miriam Walden Postdoctoral Scientist
- John Steele Postgraduate Student
- Dr Abbas Maqbool Postdoctoral Scientist
- Dr Richard Hughes Research Assistant
- Benjamin Hall Postgraduate Student
- Dr Marina Franceschetti Postdoctoral Scientist
- Bushra Azmat Postgraduate Student
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