Plants recurrently produce new organs and tissues at the apical meristems, whose activity establishes plant architecture and is key to crop productivity.
The Sablowski lab works on the genetics and cell biology of meristem and early organ development in the model plant species, Arabidopsis thaliana and in related crop species (Brassica spp).
One of their main current interests is how the stem is initiated in the subapical region of the shoot meristem. They use a combination of quantitative imaging, genetics and genome-wide association mapping to understand how stem development is regulated and to reveal novel genes that can be used to modify stem architecture.
At a more fundamental level, we study how regulatory genes coordinate cell division and cell growth during plant organogenesis. To study this question, the Sablowski lab use quantitative, live imaging of cell division and growth, combined with global analysis of genes targeted by key regulators of plant organ growth.
Ultimately, their work aims to reveal fundamental principles of plant development to allow rational modification of plant organ growth and crop performance.
Serrano-Mislata A., Bencivenga S., Bush M., Schiessl K., Boden S., Sablowski R. (2017)DELLA genes restrict inflorescence meristem function independently of plant height.Nature plants (Aug 21 2017)Publisher's version: 2055-0278
Bencivenga S., Serrano A., Bush M., Fox S., Sablowski R. (2016)Control of oriented tissue growth through repression of organ boundary genes promotes stem morphogenesisDevelopmental Cell (39)Publisher's version: NA
Serrano A., Schiessl K., Sablowski R. (2015)Active Control of Cell Size Generates Spatial Detail during Plant Organogenesis.Current Biology (25)Publisher's version: 0960-9822