Prof Mark Buttner

Head of Department
Molecular Microbiology

Research in our lab focusses on the cell biological processes underpinning Streptomyces sporulation, the master regulators that control these processes, and the regulatory networks that link the two. 

Our approach exploits a broad range of disciplines including cell biology, modelling, global ‘omics’ methods, genetics and biochemistry, right through to X-ray crystallography. As part of our work, we have recently pioneered the development of Streptomyces venezuelae as a new model system for the genus. Unlike most Streptomyces species, S. venezuelae sporulates in liquid culture, giving us a unique opportunity to follow the movement of multiple developmental proteins in time and space during differentiation using time-lapse imaging (movies). Sporulation in liquid culture also allows us to optimally apply global approaches like microarray transcriptional profiling and ChIP-seq to the analysis of cellular differentiation. 

In addition to our developmental research, we also investigate the molecular mechanisms that mediate oxidative and cell envelope stress responses in Streptomyces, and those involved in the control of antibiotic resistance, focussing on key components of each signal transduction pathway.

New book profiles Professor Sir David Hopwood's remarkable career

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Sporulation mystery solved

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Recent Publications

Schlimpert S., Wasserstrom S., Chandra G., Bibb M. J., Findlay K. C., Flärdh K., Buttner M. J. (2017)

Two dynamin-like proteins stabilize FtsZ rings during Streptomyces sporulation.

Proceedings of the National Academy of Sciences of the United States of America tbc ptbc

Publisher’s version: 10.1073/pnas.1704612114

Bush M., Chandra G., Findlay K., Buttner M. (2017)

Multi-layered inhibition of Streptomyces development: BldO is a dedicated repressor of whiB

Molecular Microbiology 104 p700-711

Publisher’s version: 10.1111/mmi.13663

Feeney M. A., Chandra G., Findlay K. C., Paget M. S. B., Buttner M. J. (2017)

Translational Control of the SigR-Directed Oxidative Stress Response in Streptomyces via IF3-Mediated Repression of a Noncanonical GTC Start Codon.

mBio 8 pe00815-17

Publisher’s version: 10.1128/mBio.00815-17

Schumacher M. A., Zeng W., Findlay K. C., Buttner M. J., Brennan R. G., Tschowri N. (2017)

The Streptomyces master regulator BldD binds c-di-GMP sequentially to create a functional BldD2-(c-di-GMP)4 complex.

Nucleic acids research 45 p6923-6933

Publisher’s version: 10.1093/nar/gkx287

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Mark Buttner

Media

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