Cell & Developmental Biology
How do small groups of cells in microscopic buds turn themselves into the diverse flower and leaf shapes we see around us? To answer this question we need to know how genes and growth interact to create tissue shapes during development, and how this process varies to produce such a remarkable range of forms. We use a highly integrative approach that combines molecular, genetic, imaging, population, ecological and computational approaches to address this problem, applying them to model systems such as Arabidopsis and Antirrhinum.
Abley K., De Reuille P. B., Strutt D., Bangham A., Prusinkiewicz P., Maree A. F., Grieneisen V. A., Coen E. (2013)
An intracellular partitioning-based framework for tissue cell polarity in plants and animals.
Development 140 (10) 2061-74
Sauret-GŁeto S., Schiessl K., Bangham A., Sablowski R., Coen E. (2013)
JAGGED Controls Arabidopsis Petal Growth and Shape by Interacting with a Divergent Polarity Field.
PLoS Biology 11 (4) e1001550
Kuchen E. E., Fox S., de Reuille P. B., Kennaway R., Bensmihen S., Avondo J., Calder G. M., Southam P., Robinson S., Bangham A., Coen E. (2012)
Generation of leaf shape through early patterns of growth and tissue polarity.
Science 335 (6072) 1092-6
Robinson S., de Reuille P., Chan J., Bergmann D., Prusinkiewicz P., Coen E. S. (2011)
Generation of spatial patterns through cell polarity switching
Science 333 (6048) 1436-1440
Kim M., Cui M. L., Cubas P., Gillies A., Lee K., Chapman M. A., Abbott R. J., Coen E. (2008)
Regulatory genes control a key morphological and ecological trait transferred between species
Science 322 1116-1119
Raimundo J., Sobral R., Bailey P., Azevedo H., Galego L., Almeida J., Coen E., Costa M. M. (2013)
A subcellular tug of war involving three MYB-like proteins underlies a molecular antagonism in Antirrhinum flower asymmetry.
Plant Journal 10 12225