As an Emeritus Fellow, Mark no longer runs a research group but interacts closely with other members of the Streptomyces group and continues to contribute to the advancement of our science.
Mark’s research focused on the cell biological processes underpinning Streptomyces sporulation, the master regulators that control these processes, and the regulatory networks that link the two.
As part of his work, he pioneered the development of Streptomyces venezuelae as a new model system for the genus. Unlike most Streptomyces species, S. venezuelae sporulates in liquid culture, giving a unique opportunity to follow the movement of multiple developmental proteins in time and space during differentiation using time-lapse imaging, and to optimally apply global approaches like transcriptional profiling and ChIP-seq to the analysis of cellular differentiation.
Mark is Co-Editor-in-Chief of Current Opinion in Microbiology Current Opinion in Microbiology | Journal | ScienceDirect.com by Elsevier
Gallagher K. A., Schumacher M. A., Bush M. J., Bibb M. J., Chandra G., Holmes N. A., Zeng W., Henderson M., Zhang H., Findlay K. C., Brennan R. G., Buttner M. J. (2020)c-di-GMP arms an anti-σ to control progression of multicellular differentiation in StreptomycesMolecular Cell (77)Publisher's version: 1097-2765
Becher P. G., Verschut V., Bibb M. J., Bush M. J., Molnár B. P., Barane E., Al-Bassam M. M., Chandra G., Song L., Challis G. L., Buttner M. J., Flärdh K. (2020)Developmentally regulated volatiles geosmin and 2-methylisoborneol attract a soil arthropod to Streptomyces bacteria promoting spore dispersal.Nature microbiology (5)Publisher's version: 2058-5276
Schlimpert S., Wasserstrom S., Chandra G., Bibb M. J., Findlay K. C., Flärdh K., Buttner M. J. (2017)Two dynamin-like proteins stabilize FtsZ rings during Streptomyces sporulation.Proceedings of the National Academy of Sciences of the United States of America (114)Publisher's version: 0027-8424