Dr Yiliang Ding
Cell and Developmental Biology
Post-transcriptional regulation of genes has gained much attention in recent years because of its direct and rapid regulation of protein levels. Our previous research has developed two novel and powerful platforms to study RNA structure in vivo and across diverse species at both the genome-wide scale (Ding et al., 2014 Nature) and in individual RNAs (Kwok et al., 2013 Nature Communications). These breakthroughs have removed technological barriers and opened up new avenues for RNA biology research. Our lab utilizes multidisciplinary knowledge and approaches in areas of Nucleic Acid Chemistry, RNA Biology and Bioinformatics.
Our research focuses on:
1. Determining the role of RNA structure in the post-transcriptional regulation of gene expression including translation, polyadenylation, RNA splicing, RNA stability and RNA processing.
2. Exploring how RNA structures alter in response to environmental changes.
3. Developing new experimental and analytical approaches for revealing RNA structure and RNA-protein interactions.
Our lab is seeking enthusiastic and highly motivated people with interests in studying these new avenues.
ContactTel: 01603 450266
Bioinformatics Sep 22 2016 p1-3
Publisher’s version: 10.1093/bioinformatics/btw611
The NIN Transcription Factor Coordinates Diverse Nodulation Programs in Different Tissues of the Medicago truncatula Root.
Plant Cell 27 p3410-24
Publisher’s version: 10.1105/tpc.15.00461
Nature protocols 10 p1050-66
Publisher’s version: 10.1038/nprot.2015.064
Biochemical Journal 467 p91-102
Publisher’s version: 10.1042/BJ20141063
Nature 505 (7485) p696-700
Publisher’s version: 10.1038/nature12756
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