Prof Mike Bevan
Cell and Developmental Biology
The final sizes of organisms are key defining features, but surprisingly little is known about the mechanisms that establish the final sizes of organs such as leaves, flowers and seeds. Both evolution and domestication have radically reshaped and resized plant organs, therefore it is important to understand the mechanisms underlying this plasticity. As organ sizes are important agricultural traits, these mechanisms are important targets for creating crops with improved yields.
My lab is using Arabidopsis thaliana, a small experimental plant, to identify mechanisms setting the final sizes of organs. These work at multiple levels to control the numbers and sizes of cells forming organs. We study a mechanism that sets the duration of cell proliferation during organ growth. The mechanism functions to coordinate the cleavage and destruction of diverse proteins that promote cell proliferation and inhibit cell differentiation. Currently our main interests are in the “upstream” regulation of this mechanism, and “downstream” consequences in terms of cell behavior. We have identified several important regulatory genes and shown that they can be used to alter seed size in crops.
I am also interested in the structure of plant genomes, as this knowledge provides fundamentally important resources and a key framework for crop improvement. Current projects include wheat genome sequencing and the assessing the influence of polyploidy on gene function and composition. This work underpins breeding and gene discovery projects in this important global crop.
I was born in Otorohanga, New Zealand, in 1952 and was a pupil at Otewa School and Hamilton Boys’ High School. I went to The University of Auckland (1970-1974) where I graduated with an MSc (Hons) in Biochemistry. I then completed post-graduate studies in plant biochemistry at the University of Cambridge (Corpus Christi College) with Professor Don Northcote.My post-doctoral studies in bacterial genetics with Professor Mary-Dell Chilton at Washington University in St Louis involved developing gene transfer and expression systems using Agrobacterium tumefaciens T-DNA components.
I started work at the Plant Breeding Institute in Cambridge in 1982 and moved to the John Innes Centre in Norwich in 1990, where I have been a Strategic Programme Leader, Acting Director and Deputy Director.
ContactTel: 01603 450520
New wheat genome sequence assembly is most accurate and complete everread more
Milestone resource in wheat research now available for downloadread more
Ubiquitylation activates a peptidase that promotes cleavage and destabilization of its activating E3 ligases and diverse growth regulatory proteins to limit cell proliferation in Arabidopsis.
Genes & Development 31 p197-208
Publisher’s version: 10.1101/gad.292235.116
The Mediator complex subunits MED25/PFT1 and MED8 are required for transcriptional responses to changes in cell wall arabinose composition and glucose treatment in Arabidopsis thaliana.
BMC Plant Biology 15 p215
Publisher’s version: 10.1186/s12870-015-0592-4
Plant Physiology 168 p1000-1012
Publisher’s version: 10.1104/pp.15.00288
The Ubiquitin Receptors DA1, DAR1, and DAR2 Redundantly Regulate Endoreduplication by Modulating the Stability of TCP14/15 in Arabidopsis.
Plant Cell 27 p649-62
Publisher’s version: 10.1105/tpc.114.132274
Elected to European Molecular Biology Organisation, 2001
Kumho Award, 2001
Rank Prize for Nutrition, 1987
Broodbank Fellow, 1976-9