Seung lab publications

Publications authored by Dr. David Seung. For the most up-to-date list, please see Dr. David Seung’s Google Scholar page.


Kamble NU, Makhamadjonov F, Fahy B, Martins C, Saalbach G, Seung D (2023). Initiation of B-type starch granules in wheat endosperm requires the plastidial α-glucan phosphorylase PHS1. Plant Cell.

Chen J*, Watson-Lazowski A*, Kamble NU, Vickers M, Seung D (2023). Gene expression profile of the developing endosperm in durum wheat provides insight into starch biosynthesis. BMC Plant Biology 23: 363.

Esch L, Ngai QY, Barclay JE, McNelly R, Hayta S, Smedley M, Smith AM, Seung D (2023). Modification of amyloplast size in wheat endosperm through mutation of PARC6 affects starch granule morphology. New Phytologist 240: 224-241.

Liu C, Pfister B, Osman R, Ritter M, Heutinck A, Sharma M, Eicke S, Fischer-Stettler M, Seung D, Bompard C, Abt M, Zeeman SC (2023). LIKE EARLY STARVATION 1 and EARLY STARVATION 1 promote and stabilize amylopectin phase transition in starch biosynthesis. Science Advances 9(21) eadg7448.

Zafeiriou P, Savva GM, Ahn-Jarvis JH, Warren FJ, Pasquariello M, Griffiths S, Seung D, Hazard BA (2023). Mining the AE Watkins wheat landrace collection for variation in starch digestibility using a new high-throughput assay. Foods 12(2):266.


Chen J, Chen Y, Watson-Lazowski A, Hawkins E, Barclay JE, Fahy B, Denley Bowers R, Corbin K, Warren FJ, Blennow A, Uauy C, Seung D (2022). The plastidial protein MRC promotes starch granule initiation in wheat leaves but delays B-type granule initiation in the endosperm. BioRxiv preprint.

Esch L, Ngai QY, Barclay JE, Smith AM, Seung D (2022). AtFZL is required for correct starch granule morphology in Arabidopsis chloroplasts. BioRxiv preprint.

Yilmazer I, Abt MR, Liang Y, Seung D, Zeeman SC, Sharma M (2022). Determining protein-protein interaction with GFP-trap beads. In: Sharma, M. (eds) Fluorescent Proteins. Methods in Molecular Biology, vol 2564. Humana, New York, NY.

Watson-Lazowski A, Raven E, Feike D, Hill L, Barclay JE, Smith AM, Seung D (2022). Loss of PROTEIN TARGETING TO STARCH 2 has variable effects on starch synthesis across organs and species. Journal of Experimental Botany. erac268,


Hawkins E, Chen J, Watson-Lazowski A, Ahn-Jarvis J, Barclay JE, Fahy B, Hartley M, Warren F, Seung D (2021). STARCH SYNTHASE 4 is required for normal starch granule initiation in amyloplasts of wheat endosperm. New Phytologist 230(6):2371-2386.

Chen J*, Hawkins E*, Seung D (2021). Towards targeted starch modification in plants. Current Opinion in Plant Biology 60:102013.


Abt M, Pfister B, Sharma M, Eicke S, Bürgy L, Neale I, Seung D, Zeeman SC (2020). STARCH SYNTHASE 5, a noncanonical starch synthase-like protein, promotes starch granule initiation in Arabidopsis. Plant Cell 32(8): 2543-2565.

Seung D (2020). Amylose in starch: Towards an understanding of biosynthesis, structure and function (Tansley Review). New Phytologist 228: 1490-1504.

Seung D, Echevarria-Poza A, Steuernagel B, Smith AM (2020). Natural polymorphisms in Arabidopsis result in wide variation or loss of the amylose component of starch. Plant Physiology 182(2): 870-881.

Chia T, Chirico M*, King R*, Ramirez-Gonzalez R*, Saccomanno B*, Seung D*, Simmonds J*, Trick M*, Uauy C*, Verhoeven T*, Trafford K (2020). A carbohydrate-binding protein, B-GRANULE CONTENT 1, influences starch granule size distribution in a dose-dependent manner in polyploid wheat. Journal of Experimental Botany 71(1): 105-115.


Gurrieri L, Distefano L, Pirone C, Horrer D, Seung D, Zaffagnini M, Rouhier N, Trost P, Sparla F, Santelia D (2019). The thioredoxin-regulated α-amylase 3 of Arabidopsis thaliana is a target of S-glutathionylation. Frontiers in Plant Sciences 10: 993.

Schreier TB, Umhang M, Lee SK, Lue WL, Shen Z, Silver D, Graf A, Müller A, Eicke S, Stadler-Waibel M, Seung D, Bischof S, Briggs SP, Kötting O, Moorhead GBG, Chen J, Zeeman SC (2019). LIKE SEX4 1 acts as a β-amylase-binding scaffold at the starch granule during starch degradation. Plant Cell 31(9): 2169-2186.

Seung D, Smith AM (2019). Starch granule initiation and morphogenesis – progress in Arabidopsis and cereals. Journal of Experimental Botany 70(3): 771-784.


Bull SE, Seung D, Chanez C, Mehta D, Kuon JE, Truernit E, Hochmuth A, Zurkirchen I, Zeeman SC, Gruissem W, Vanderschuren H (2018). Accelerated ex situ breeding of GBSS- and PTST1-edited cassava for modified starch. Science Advances 4(9): eaat6086

Seung D†, Schreier TB, Bürgy L, Eicke S, Zeeman SC† (2018). Two plastidial coiled coil proteins are essential for normal starch granule initiation in Arabidopsis. Plant Cell 30: 1523-1542


Seung D, Boudet J, Monroe J, Schreier TB, Abt M, Lu KJ, Zanella M, Zeeman SC (2017). Homologs of PROTEIN TARGETING TO STARCH control starch granule initiation in Arabidopsis leaves. Plant Cell 29: 1657-1677.

Eicke S, Seung D, Egli B, Devers EA, Streb S (2017). Increasing the carbohydrate storage capacity of plants by engineering a glycogen-like polymer pool in the cytosol. Metabolic Engineering 40: 23-32.


Seung D, Lu KJ, Stettler M, Streb S, Zeeman SC (2016). Degradation of glucan primers in the absence of STARCH SYNTHASE 4 disrupts starch granule initiation in Arabidopsis. Journal of Biological Chemistry 291(39): 20718-20728.

Thalmann M, Pazmino D, Seung D, Horrer D, Nigro A, Meier T, Kölling K, Pfeihofer HW, Zeeman SC, Santelia D (2016). Regulation of leaf starch degradation by abscisic acid is important for osmotic stress tolerance in plants. Plant Cell 28: 1860-1878.

Feike D*, Seung D*, Graf A, Bischof S, Ellick T, Coiro M, Soyk S, Eicke S, Mettler-Altmann T, Lu KJ, Trick M, Zeeman SC, Smith AM (2016). The starch granule-associated protein EARLY STARVATION1 (ESV1) is required for the control of starch degradation in Arabidopsis thaliana leaves. Plant Cell 28: 1472-1489.


Seung D, Soyk S, Coiro M, Maier B, Eicke S, Zeeman SC (2015). PROTEIN TARGETING TO STARCH is required for localising GRANULE BOUND STARCH SYNTHASE to starch granules and for normal amylose synthesis in Arabidopsis. PLOS Biol 13(2): e1002080.

Seung D, Thalmann M, Sparla F, Hachem MA, Lee SK, Issakidis-Bourget E, Svensson B, Zeeman SC, Santelia D (2013). Arabidopsis thaliana AMY3 is a unique redox-regulated chloroplastic α-amylase. Journal of Biological Chemistry 288: 33620-33633.

Seung D, Webster MW, Wang R, Andreeva Z, Marc J (2013). Dissecting the mechanism if abscisic acid-induced dynamic microtubule reorientation using live cell imaging. Functional Plant Biology 40: 224-236.

McIntyre CL, Seung D, Casu RE, Rebetzke GJ, Shorter R, Xue GP (2012). Genotypic variation in the accumulation of water soluble carbohydrates in wheat. Functional Plant Biology 39: 560-568.

Seung D*, Risopatron JPM*, Jones BJ, Marc J (2012). Circadian clock-dependent gating in ABA signalling networks. Protoplasma 249(3): 445-457.

Santelia D, Kötting O, Seung D, Schubert M, Thalmann M, Meekins D, Lutz A, Patron N, Gentry MS, Allain F, Zeeman SC (2011). The phosphoglucan phosphatase Like Sex Four2 dephosphorylates starch at the C3-position in Arabidopsis. Plant Cell 23: 4096-4111.

Grant A, Trompf K, Seung D, Nivison-Smith L, Bowcock H, Kresse H, Holmes S, Radford J, Morrow P (2010). Sub-cellular damage by copper in the cnidarian Zoanthus robustus. Comparative Biochemistry and Physiology C 152(3): 256-262.

Wilkes MA, Seung D, Levavasseur G, Trethowan RM, Copeland L (2010). Environmental effects on protein and starch quality of three related wheat genotypes. Cereal Chemistry 87(2): 95-99.