Caroline’s research investigate genes that are involved in determining the final size of plant seeds and organs.
Using Arabidopsis thaliana as a model plant, Caroline is dissecting the factors that determine the number of cells, and what signals the end of cell proliferation prior to cell expansion.
By understanding more about these processes there is the potential to increase yield in crop plants.
Caroline uses a variety of techniques from plant tissue culture, transient expression in protoplasts, confocal microscopy and protein work.
Seguela-Arnaud M., Smith C., Uribe M. C., May S., Fischl H., McKenzie N., Bevan M. W. (2015)The Mediator complex subunits MED25/PFT1 and MED8 are required for transcriptional responses to changes in cell wall arabinose composition and glucose treatment in Arabidopsis thaliana.BMC Plant Biology (15)Publisher's version: 1471-2229
Dong H., Dumenil J., Lu F. H., Na L., Vanhaeren H., Naumann C., Klecker M., Prior R., Smith C., McKenzie N., Saalbach G., Chen L., Xia T., Gonzalez N., Seguela M., Inze D., Dissmeyer N., Li Y., Bevan M. W. (2017)Ubiquitylation activates a peptidase that promotes cleavage and destabilization of its activating E3 ligases and diverse growth regulatory proteins to limit cell proliferation in Arabidopsis.Genes & Development (31)Publisher's version: 0890-9369