Dr Jacob Malone
My lab uses a combination of genetics, molecular microbiology and biochemistry to address the molecular mechanisms underlying bacterial signal transduction during responses to the environment. The commensal soil bacterium Pseudomonas fluorescens is a prominent biocontrol species that forms non-specific, beneficial relationships with plants and suppresses fungal growth. Pseudomonas syringae on the other hand is an aggressive plant pathogen.
Recent work from our laboratory and others has identified an important role for the ubiquitous bacterial second messenger cyclic-di-GMP in the control of P. fluorescens root colonisation and P. syringae plant infection. Cyclic-di-GMP is found in almost every bacterial species on Earth, and is a critical component of the intracellular signalling machinery that controls bacterial behaviour. My group are currently working to functionally characterise the cyclic-di-GMP pathways that operate during Pseudomonas interactions with plants, with the overall aim of constructing integrated molecular models for cyclic-di-GMP signalling in these important plant-associated species.
One ligand, two regulators and three binding sites: How KDPG controls primary carbon metabolism in Pseudomonas.
PLoS Genetics 13 pe1006839
Publisher’s version: 10.1371/journal.pgen.1006839
Indexing the Pseudomonas specialized metabolome enabled the discovery of poaeamide B and the bananamides.
Nature microbiology 2 p16197
Publisher’s version: 10.1038/nmicrobiol.2016.197
- Dr Richard Little Research Assistant
- Eleftheria Trampari Postgraduate Student
- Dr Rosaria Campilongo Visiting Worker
- Dr Lucia Grenga Visiting Worker
- Kieran Rustage Undergraduate Project Student
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Expertise: Bacterial signalling, plant growth-promoting bacteria, biocontrol