Dr Jacob Malone
My lab uses a combination of genetics, molecular microbiology and biochemistry to address the molecular mechanisms underlying bacterial signal transduction during responses to the environment. The commensal soil bacterium Pseudomonas fluorescens is a prominent biocontrol species that forms non-specific, beneficial relationships with plants and suppresses fungal growth. Pseudomonas syringae on the other hand is an aggressive plant pathogen.
Recent work from our laboratory and others has identified an important role for the ubiquitous bacterial second messenger cyclic-di-GMP in the control of P. fluorescens root colonisation and P. syringae plant infection. Cyclic-di-GMP is found in almost every bacterial species on Earth, and is a critical component of the intracellular signalling machinery that controls bacterial behaviour. My group are currently working to functionally characterise the cyclic-di-GMP pathways that operate during Pseudomonas interactions with plants, with the overall aim of constructing integrated molecular models for cyclic-di-GMP signalling in these important plant-associated species.
Indexing the Pseudomonas specialized metabolome enabled the discovery of poaeamide B and the bananamides.
Nature microbiology 2 p16197
Publisher’s version: 10.1038/nmicrobiol.2016.197
A Minimal Threshold of c-di-GMP Is Essential for Fruiting Body Formation and Sporulation in Myxococcus xanthus.
PLoS Genetics 12 pe1006080
Publisher’s version: 10.1371/journal.pgen.1006080
Molecular Plant Pathology not yet given pnot yet given
Publisher’s version: 10.1111/mpp.12427
Adaptive remodeling of the bacterial proteome by specific ribosomal modification regulates Pseudomonas infection and niche colonisation
PLoS Genetics 12 (2) pe1005837
Publisher’s version: 10.1371/journal.pgen.1005837
An analysis of Pseudomonas genomic diversity in take-all infected wheat fields reveals the lasting impact of wheat cultivars on the soil microbiota.
Environmental Microbiology 17 (11) p47644778
Publisher’s version: 10.1111/1462-2920.13038
- Dr Richard Little Research Assistant
- Eleftheria Trampari Postgraduate Student
- Dr Rosaria Campilongo Visiting Worker
- Dr Lucia Grenga Visiting Worker
- Kieran Rustage Undergraduate Project Student
For media enquiries, please contact the JIC communications team 01603 450962, firstname.lastname@example.org
Expertise: Bacterial signalling, plant growth-promoting bacteria, biocontrol