Friday Seminar; Cell proliferation during organogenesis: more complex than anticipated

Our next Friday Seminar takes place in the Merton Auditorium at 11:30am on Friday 13 December.

Speaker

Professor Crisanto Gutierrez, Centro De Biologia Molecular

Title

‘Cell proliferation during organogenesis: more complex than anticipated

Synopsis

Organ development depends on a finely regulated cellular homeostasis that involves cell production and cell differentiation.

Stem cells produce derivatives that constitute the transient amplifying compartment where cell exit and cell production are in equilibrium to maintain the organ steady-state size.

The root consists of well-defined anatomical and functional zones. Recent results indicate that different zones and cell types possess unique proliferation kinetics that can be related to chromatin dynamics and turnover of cell cycle proteins.

I will discuss the unforeseen complexities in cell proliferation control with an integrative approach linking cell division potential, genome replication and chromatin dynamics

Professor Crisanto Gutierrez biography

Professor Crisanto Gutierrez is Professor of the Spanish Research Council (CSIC) at the Centro de Biologia Molecular “Severo Ochoa” (Madrid), where he is currently Director of the Department of Genome Dynamics and Function.

He received a BSc by the University of Seville and a PhD by the University Autonoma of Madrid (1980). Then, he worked as Assistant Professor of Cell Biology in Madrid before moving first to Harvard University and, then, to the Roche Institute of Molecular Biology where he studied SV40 DNA replication (1982-1990). After his return to Madrid, he started to use geminiviruses as a model to study DNA replication in plants, leading to advances in the field of geminivirus biology and plant cell cycle, such us the retinoblastoma/E2F pathway. More recently, he has focused on the relationships between cell proliferation, epigenetics and DNA replication during development.

Cristanto is an Elected Member of the European Molecular Biology Organisation (EMBO), belongs to the editorial advisory board of EMBO J. and EMBO Rep., is Editor of Plant J., and serves in the Scientific Advisory Board several research Institutes.

 

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