Friday Seminar; How to build an endospore and accelerate antibiotic drug discovery

Our next Friday Seminar takes place in the Merton Auditorium at 11:30am on Friday 1 November.

Speaker

Professor Kit Pogliano, University of California, San Diego

Title

How to build an endospore and accelerate antibiotic drug discovery

Synopsis

Despite the growing appreciation that the bacterial cell is highly dynamic and spatially regulated, it remains a cell biological enigma, as we lack mechanistic explanations for many conserved and essential cellular processes.

The Pogliano lab develops new cell biological and genetic tools to study bacterial cells, focusing on sporulation and interspecies interactions.

First she will describe our studies on engulfment, a phagocytosis-like process that mediates a striking reorganisation of the Bacillus subtilis sporangium, from two cells that lie side by side, to an endospore in which one cell lies within the cytoplasm of another. Engulfment provides an ideal system to study how bacterial cells move macromolecules, localise proteins, catalyse membrane fission and coordinate the biosynthesis of essential spore components during starvation.

Next, Kit will describe genetics and cell biology enabled shortcuts for the discovery of new antibiotics to treat drug resistant bacterial infections.

Professor Kit Pogliano biography

Kit Pogliano received her PhD. from the Department of Microbiology and Molecular Genetics at Harvard Medical School and was a Damon Runyon-Walter Winchell postdoctoral fellow at Harvard University. She is a recipient of the Searle Scholar and Beckman Young Investigator awards and was named in 2009 as a Fellow in the American Academy of Microbiology.

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