Prof Graham Moore
Programme Leader (Designing Future Wheat)
Graham’s research provides an understanding of chromosome pairing within wheat and enables the incorporation of genes from wild relatives into the wheat genome to provide beneficial traits for yield and resilience.
His research has focused on recombination within the cereals.
Graham is also working to understand the genes involved in the temperature sensitivity of meiosis which will be important for growing wheat in a warming environment.
- Wheat breeding
- Genetic recombination in wheat and cereals
- The effect of temperature on meiosis
Inducing chromosomes derived from different wheat varieties to recombine is fundamental to plant breeding. Fertility of polyploid species, such as many flowering plants, depends on pairing and recombination at meiosis occurring only between true homologous chromosomes. Pairing between the highly related, but more diverged homoeologous chromosomes also present does not produce fertile plants.
In hexaploid wheat, a single major locus (Ph1) ensures that chromosome pairing and recombination at meiosis is restricted to true homologues. Investigating the mechanism of Ph1 provides novel insights into the control and regulation of homologue recognition and crossover. To this end, Graham's group developed the concept of cereal synteny and applied this to characterize the Ph1 locus. At the same time, in collaboration with Peter Shaw, they have been applying cell biology approaches to investigate the Ph1 mechanism.
The group is also involved in understanding the effect of temperature on wheat meiosis, and its subsequent effect on seed set; and in characterizing the gametocidal locus, which is involved in inducing chromosome fragmentation during pollen mitosis.
Professor Graham Moore recognised for exceptional contribution to wheat researchread more
New wheat genome sequence assembly is most accurate and complete to dateread more
Chromosoma not yet available pnot yet available
Publisher’s version: 10.1007/s00412-017-0630-0
Nature Plants 1 p15018
Publisher’s version: 10.1038/NPLANTS.2015.18
Nature Communications 5 p5580
Publisher’s version: 10.1038/ncomms5580
Molecular characterization of Ph1 as a major chromosome pairing locus in polyploid locus in polyploid wheat
Nature 439 p749-752
Publisher’s version: 10.1038/nature04434
Nature Cell Biology 6 p906-908
Publisher’s version: 10.1038/s41477-017-0083-8
Exploiting the ZIP4 homologue within the wheat Ph1 locus has identified two lines exhibiting homoeologous crossoverin wheat-wild relative hybrids
Molecular Breeding 37 p95
Publisher’s version: 10.1007/s11032-017-0700-2
Short periods of high temperature during meiosis prevent normal meiotic progression and reduce grain number in hexaploid wheat (Triticum aestivum L.).
TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik N/A pN/A
Publisher’s version: 10.1007/s00122-017-2925-1
- Dr Azahara Carmen Martin Postdoctoral Scientist
- Tracie Draeger Research Assistant
- Maria Santome Research Fellow
- Liz Sayers Research Assistant
Royal Society Darwin Medal (jointly with Professor Mike Gale), 1998
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