Dr Cristobal Uauy

Project Leader
Crop Genetics

Our lab seeks to identify genes underlying wheat QTL with significant agronomic impact, understand the mechanism by which they function and using this knowledge, facilitate their effective deployment into modern breeding varieties.

We are currently using molecular genetics approaches to:

  • identify the genes responsible for key yield and quality traits in UK wheat germplasm,
  • understand the interaction between wheat and the yellow rust fungal pathogen
  • develop genetic resources to enable effective translational research from model systems to crop species,
  • enhance the pipeline to translate this new knowledge into improved wheat varieties for growers, industry and consumers.


Tel: 01603 450195

John Innes Centre scientists use CRISPR technology to edit crop genes - subsequent generations contain no transgenes

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Scientists close the gap on devastating cereal killer

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Wheat Diseases Conference - 22nd May 2015

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Global surveillance leaves Cereal Killers nowhere to hide

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Selected Publications

Uauy C., Paraiso F., Colasuonno P., Tran R., Tsai H., Berardi S., Comai L., Dubcosvky J. (2009)

A modified TILLING approach to detect induced mutations in tetraploid and hexaploid wheat

BMC Plant Biology 9 pArt: 115

Fu D., Uauy C., Blechl A., Dubcovsky J. (2007)

RNA interference for wheat functional gene analysis.

Transgenic Research 16 p689-701

Publisher’s version: 10.1007/s11248-007-9150-7

Distelfeld A., Uauy C., Fahima T., Dubcovsky J. (2006)

Physical map of the wheat high-grain protein content gene Gpc-B1 and development of a high-throughput molecular marker.

New Phytologist 169 p753-63

Publisher’s version: 10.1111/j.1469-8137.2005.01627.x

Uauy C., Distelfeld A., Fahima T., Blechl A., Dubcovsky J. (2006)

A NAC Gene regulating senescence improves grain protein, zinc, and iron content in wheat.

Science 314 p1298-301

Publisher’s version: 10.1126/science.1133649

Uauy C., Brevis J. C., Dubcovsky J. (2006)

The high grain protein content gene Gpc-B1 accelerates senescence and has pleiotropic effects on protein content in wheat.

Journal of Experimental Botany 57 p2785-94

Publisher’s version: 10.1093/jxb/erl047

Recent Publications

Simmonds J., Scott P., Brinton J., Mestre T. C., Bush M., Del Blanco A., Dubcovsky J., Uauy C. (2016)

A splice acceptor site mutation in TaGW2-A1 increases thousandgrain weight in tetraploid and hexaploid wheat through widerand longer grains

Theoretical and Applied Genetics in press pin press

Publisher’s version: 10.1007/s00122-016-2686-2

Borrill P., Ramirez-Gonzalez R., Uauy C. (2016)

expVIP: a customisable RNA-seq data analysis and visualisation platform.

Plant Physiology in press pin press

Publisher’s version: 10.1104/pp.15.01667

Lawrenson T., Shorinola O., Stacey N., Li C., Ostergaard L., Patron N., Uauy C., Harwood W. (2015)

Induction of targeted, heritable mutations in barley and Brassica oleracea using RNA-guided Cas9 nuclease.

Genome Biology 16 p258

Publisher’s version: 10.1186/s13059-015-0826-7

Ramirez Gonzalez R. H., Segovia V., Bird N., Caccamo M., Uauy C. (2015)

Next Generation Sequencing Enabled Genetics in Hexaploid Wheat

View All

Cristobal Uauy

  • Nikolai Adamski Postdoctoral Scientist
  • Momina Hussain Visiting Worker
  • Peter Scott Support Specialist
  • Tobin Florio Research Assistant
  • James Simmonds Research Assistant
  • Oluwaseyi Shorinola Postgraduate Student
  • Dr Marianna Pasquariello Research Assistant
  • Dr Clare Lewis Research Assistant
  • Amelia Frizell-Armitage Postgraduate Student
  • Jemima Florence Brinton Postgraduate Student
  • Dr Philippa Borrill Research Fellow
  • Elle Lewis-Smedley Lab Attendant


For media enquiries, please contact the JIC communications team 01603 450962,

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