Michael is a chemist, with a background in natural product total synthesis, medicinal chemistry, and pharmacy.
Within the Osbourn group Michael works at the interface between natural product chemistry and synthetic biology.
Michael’s main focus is on the application of transient expression of biosynthetic enzymes in Nicotiana benthamiana leaves for the preparative production of high-value triterpenes, and utilizing this technique to explore and engineer the chemical diversity of this family of medicinally relevant natural products.
Stephenson M. J., Reed J., Brouwer B., Osbourn A. (2018)Transient expression in Nicotiana Benthamiana leaves for triterpene production at a preparative scale.Journal of visualized experiments : JoVEPublisher's version: 1940-087X
Reed J., Stephenson M. J., Miettinen K., Brouwer B., Leveau A., Brett P., Goss R. J. M., Goossens A., O'Connell M. A., Osbourn A. (2017)A translational synthetic biology platform for rapid access to gram-scale quantities of novel drug-like molecules.Metabolic Engineering (42)Publisher's version: 1096-7176
Stephenson M. J., Howell L. A., O'Connell M. A., Fox K. R., Adcock C., Kingston J., Sheldrake H., Pors K., Collingwood S. P., Searcey M. (2015)Solid-Phase Synthesis of Duocarmycin Analogues and the Effect of C-Terminal Substitution on Biological Activity.The Journal of organic chemistry (80)Publisher's version: 0022-3263