Clare works for David Lawson on the Protein Crystallography platform. The Protein Crystallography team use X-ray crystallography to reveal the atomic details of biological systems providing deep insights into molecular interactions, gene regulation, enzyme mechanism, protein function and protein evolution.
She manages the Biophysical Analysis platform which has two techniques (Surface Plasmon Resonance and Isothermal Titration Calorimetry) that can be used to study a wide range of biomolecular interactions and a third technique Circular Dichroism spectroscopy) that can be used to look at the secondary structure of proteins.
Clare is also the lead for the Technician Commitment at the John Innes Centre.
Franceschetti M,Banfield M,Stevenson C,De la Concepcion JC (2020)In vitro Assessment of Pathogen Effector Binding to Host Proteins by Surface Plasmon ResonanceBio-Protocol (Vol 10)Publisher's version: 10.21769
Jalal ASB,Tran NT,Stevenson CE,Chan EW,Lo R,Tan X,Noy A,Lawson DM,Le TBK (2020)Diversification of DNA-Binding Specificity by Permissive and Specificity-Switching Mutations in the ParB/Noc Protein FamilyCell Reports (32)Publisher's version: 2211-1247
Ghilarov D., Stevenson C. E. M., Travin D. Y., Piskunova J., Serebryakova M., Maxwell A., Lawson D. M., Severinov K. (2019)Architecture of Microcin B17 Synthetase: An Octameric Protein Complex Converting a Ribosomally Synthesized Peptide into a DNA Gyrase Poison.Molecular Cell (73)Publisher's version: 1097-2765