Dr Adriana Becerril Garcia

Postdoctoral Scientist

Adriana is interested in the biosynthesis of natural products. She is currently working on two projects; the first to characterise the biosynthesis of an unusual secondary metabolite by generating knockout strains and analysing their production to propose a biosynthetic pathway.

The second, in collaboration with Prof Matt Hutchings, to develop a Streptomyces based protein production platform. Many Streptomyces genes do not express efficiently in E. coli or do so but yield proteins in insoluble form or which do not fold/are not correctly modified post-translationally. However, there is no generic system/toolkit for Streptomyces expression and protein levels are often poor. Adriana is trying to develop methods and tools to address these issues.