Dr Veronica Grieneisen
Computational and Systems Biology
My Lab aims to understand spatial regulation of intracellular cell polarity, cell shape changes, and intercellular polarity coupling and signalling in morphogenesis.
To achieve this, we use a combination of approaches: mathematical and computational methods, experiments in Arabidopsis, and (most recently), 'experiences' with autonomous agents (robot swarms).
In particular, we wish to unravel the complexity of the feedbacks between subcellular mechanisms of cell polarity and tissue-level patterning mechanisms, focusing on hormonal patterning, genetic regulatory networks, biophysical interactions, and the tight-interaction between plant development and the environment.
From a theoretical standpoint, our studies allow us to gain new insights on mechanisms of biological pattern formation and principles of auto-organisation. From a practical point of view, we are interested in understanding how plants control their growth and architecture, and how they optimally regulate their intake of nutrients.
Our multi-modelling strategy captures biological processes at different levels – molecular and genetic levels, subcellular properties, cells and organs – allowing them to interact under certain hypothesis and within a 'controlled' system (which experiments do not easily permit).
Life in the fast lane: how plants avoid traffic jamsread more
Hormonal tug-of-war helps plant roots navigate their journey through the soil, new international study findsread more
Development 140 p2061-74
Publisher’s version: 10.1242/dev.062984
Current Opinion in Cell Biology 44 p51-58
Publisher’s version: 10.1016/j.ceb.2017.03.001
Parsimonious Model of Vascular Patterning Links Transverse Hormone Fluxes to Lateral Root Initiation: Auxin Leads the Way, while Cytokinin Levels Out.
PLoS Computational Biology 11 pe1004450
Publisher’s version: 10.1371/journal.pcbi.1004450
The biophysical nature of cells: potential cell behaviours revealed by analytical and computational studies of cell surface mechanics
BMC Biophysics p
Publisher’s version: 10.1186/s13628-015-0022-x
Mathematical Modeling and Experimental Validation of the Spatial Distribution of Boron in the Root of Arabidopsis thaliana Identify High Boron Accumulation in the Tip and Predict a Distinct Root Tip Uptake Function.
Plant Cell Physiology 56 p620-30
Publisher’s version: 10.1093/pcp/pcv016
Journal of Integrative Plant Biology 55 p847-63
Publisher’s version: 10.1111/jipb.12092
- Dr Ross Carter Postdoctoral Scientist
- Binish Mohammed Postdoctoral Scientist
- Nadiatul Radzman Postdoctoral Scientist
- Martin Hinsch Postdoctoral Scientist
- Dr Susana Sauret-Gueto Research Assistant
President's Medalist of the Society of Experimental Biology, 2011
Hugo de Vries Award of the Hugo de Vries Foundation and the Royal Dutch Botanical Society, 2009
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