Prof George Lomonossoff
George is a virologist who uses molecular biology to understand the assembly and properties of viruses.
He uses a synthetic biology approach to create synthetic virus-like particles.
He has exploited a highly efficient transient expression system to produce pharmacologically active proteins within plants.
George’s research uses nanotechnology to create virus-like particles which can be used for immune recognition and vaccine development, they also make good nanoparticles for drug delivery.
- Creating synthetic virus-like particles
- Using virus-like particles for drug delivery and vaccine development
- Production of proteins using a transient expression system
Research in George's lab is primarily focussed on the exploitation of plant viruses in bio- and nanotechnology technology.
The group has exploited a highly efficient transient expression system developed in their laboratory (the CPMV-HT system) to produce a range of pharmacologically active proteins, including antibodies and virus-like particles, in plants.
In the case of Bluetongue virus (BTV), plant-produced particles have been shown to be able to protect sheep against bluetongue disease. Work in this area has resulted in the filing of several patents.
The group has also been involved in projects that have demonstrated the utility of the CPMV-HT transient expression system for the analysis, manipulation and re-engineering of plant secondary metabolite biosynthetic pathways.
Research on protein expression in plants, including secondary metabolite biosynthesis, resulted in Frank Sainsbury (a Ph.D student at the John Innes Centre) and George being named BBSRC Overall Innovators of the Year in 2012
JIC spin-off Leaf Systems opened by Science Minister Jo Johnsonread more
Plant-based vaccine among front runners in search for new polio jabread more
Tandem fusion of hepatitis B core antigen allows assembly of virus-like particles in bacteria and plants with enhanced capacity to accommodate foreign proteins.
PLoS One 10 pe0120751
Publisher’s version: 10.1371/journal.pone.0120751
Biochemical analysis of a multifunction cytochrome P450 (CYP51) enzyme required for synthesis of antimicrobial triterpenes in plants
Proceedings of the National Academy of Sciences of the United States of America 110 pE3360-E3367
Publisher’s version: 10.1073/pnas.1309157110
Small 6 p818-821
Publisher’s version: 10.1002/smll.200902135
Extremely high-level and rapid transient protein production in plants without the use of viral replication
Plant Physiology 148 p1212-1218
Publisher’s version: 10.1104/pp.108.126284
Publisher’s version: 10.1039/c7nr07182e
Combining high-resolution cryo-electron microscopy and mutagenesis to develop cowpea mosaic virus for bionanotechnology.
Biochemical Society Transactions 45 p1263-1269 BST-2016-0312C
Publisher’s version: 10.1042/BST20160312
In Planta Synthesis of Designer-Length Tobacco Mosaic Virus-Based Nano-Rods That Can Be Used to Fabricate Nano-Wires.
Frontiers in plant science 8 p1335
Publisher’s version: 10.3389/fpls.2017.01335
Nature communications 8 p245
Publisher’s version: 10.1038/s41467-017-00090-w
Detection of Serum Antibodies to Hepatitis E Virus Based on HEV Genotype 3 ORF2 Capsid Protein Expressed in Nicotiana benthamiana.
Annals of laboratory medicine 37 p313-319
Publisher’s version: 10.3343/alm.2017.37.4.313
- Johanna Marsian Postgraduate Student
- Dr Yulia Meshcheriakova Postdoctoral Scientist
- Hadrien Peyret Postgraduate Student
- Dr Keith Saunders Research Assistant
- Ben Duckworth Postgraduate Student
- Dr Eva Thuenemann Postdoctoral Scientist
Member of the BBSRC Innovator of the Year / Activating Impact judging panel, 2014