Dr Cristobal Uauy

Project Leader
Crop Genetics

Cristobal’s research is focused on using genetics and genomics to improve both yield and quality components in wheat.

He is using natural and induced variation to identify genes which affect cell division and expansion within the seed to improve grain weight.

He is also investigating disease resistance and ways of improving wheat quality, for example nutrient and protein content in the grain.

Cristobal has developed several functional genomics resources to aid wheat breeders and enhance scientific discovery. 

  • Markers for increased grain weight in wheat
  • Triple mutants in wheat for new traits
  • Improving wheat grain quality (nutrients and protein)

 

The lab uses molecular genetic approaches to identify genes involved in wheat productivity traits and enhance the translation of this knowledge into improved varieties for industry and consumers.

They aim to understand the mechanisms by which these genes function in order to develop the most rational strategies to deploy these genes into commercial varieties.

They're currently working to enhance wheat disease resistance and improve grain quality and yield by identifying genes related to grain size and shape.

Our impact is centred on innovations in two main areas:

  • Development of genomics-enabled technologies to accelerate plant breeding
  • Facilitating access to these technologies to a wide range of users

 

To achieve this, they have developed new tools and platforms to aid in visualisation and practical implementation of large-scale datasets into breeding practices.

Contact

Tel: 01603 450195
cristobal.uauy@jic.ac.uk

Pumping Iron – Biofortified wheat produces white flour with extra iron

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Pioneering work in wheat breeding programmes hailed in BBSRC awards

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New wheat genome sequence assembly is most accurate and complete to date

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Jemima Brinton awarded Monogram Early Career Award

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Selected Publications

Krasileva K. V., Vazquez-Gross H. A., Howell T., Bailey P., Paraiso F., Clissold L., Simmonds J., Ramirez Gonzalez R. H., Wang X., Borrill P., Fosker C., Ayling S., Phillips A., Uauy C., Dubcovsky J. (2017)

Uncovering hidden variation in polyploid wheat

Proceedings of the National Academy of Sciences of the United States of America early edition pearly edition

Publisher’s version: 10.1073/pnas.1619268114

Uauy C., Paraiso F., Colasuonno P., Tran R., Tsai H., Berardi S., Comai L., Dubcosvky J. (2009)

A modified TILLING approach to detect induced mutations in tetraploid and hexaploid wheat

BMC Plant Biology 9 pArt: 115

Fu D., Uauy C., Blechl A., Dubcovsky J. (2007)

RNA interference for wheat functional gene analysis.

Transgenic Research 16 p689-701

Publisher’s version: 10.1007/s11248-007-9150-7

Distelfeld A., Uauy C., Fahima T., Dubcovsky J. (2006)

Physical map of the wheat high-grain protein content gene Gpc-B1 and development of a high-throughput molecular marker.

New Phytologist 169 p753-63

Publisher’s version: 10.1111/j.1469-8137.2005.01627.x

Uauy C., Distelfeld A., Fahima T., Blechl A., Dubcovsky J. (2006)

A NAC Gene regulating senescence improves grain protein, zinc, and iron content in wheat.

Science 314 p1298-301

Publisher’s version: 10.1126/science.1133649

Recent Publications

Shorinola O., Balcárková B., Hyles J., Tibbits J. F. G., Hayden M. J., Holuova K., Valárik M., Distelfeld A., Torada A., Barrero J. M., Uauy C. (2017)

Haplotype Analysis of the Pre-harvest Sprouting Resistance Locus Phs-A1 Reveals a Causal Role of TaMKK3-A in Global Germplasm.

Frontiers in plant science 8 p1555

Publisher’s version: 10.3389/fpls.2017.01555

Rey M. D., Martin A., Higgins J., Swarbreck D., Uauy C., Shaw P., Moore G. (2017)

Exploiting the ZIP4 homologue within the wheat Ph1 locus has identified two lines exhibiting homoeologous crossoverin wheat-wild relative hybrids

Molecular Breeding 37 p95

Publisher’s version: 10.1007/s11032-017-0700-2

Connorton J. M., Jones E. R., Rodriguez-Ramiro I., Fairweather-Tait S., Uauy C., Balk J. (2017)

Vacuolar Iron Transporter TaVIT2 transports Fe and Mn and is effective for biofortification.

Plant Physiology TBC pTBC

Publisher’s version: 10.1104/pp.17.00672

Brinton J., Simmonds J., Minter F., Leverington-Waite M., Snape J., Uauy C. (2017)

Increased pericarp cell length underlies a major quantitative trait locus for grain weight in hexaploid wheat.

New Phytologist online ponline

Publisher’s version: 10.1111/nph.14624

Clavijo B. J., Venturini L., Schudoma C., Accinelli G. G., Kaithakottil G., Wright J., Borrill P., Kettleborough G., Heavens D., Chapman H., Lipscombe J., Barker T., Lu F. H., McKenzie N., Raats D., Ramirez R. H., Coince A., Peel N., Percival-Alwyn L., Duncan O., Trösch J., Yu G., Bolser D. M., Namaati G., Kerhornou A., Spannagl M., Gundlach H., Haberer G., Davey R. P., Fosker C., Palma F. D., Phillips A. L., Millar A. H., Kersey P. J., Uauy C., Krasileva K. V., Swarbreck D., Bevan M. W., Clark M. D. (2017)

An improved assembly and annotation of the allohexaploid wheat genome identifies complete families of agronomic genes and provides genomic evidence for chromosomal translocations.

Genome Research 27 p885-896

Publisher’s version: 10.1101/gr.217117.116

View All

Cristobal Uauy

  • Dr Nikolai Adamski Postdoctoral Scientist
  • Momina Hussain Visiting Worker
  • Peter Scott Support Specialist
  • Tobin Florio Research Assistant
  • James Simmonds Research Assistant
  • Oluwaseyi Shorinola Postgraduate Student
  • Dr Marianna Pasquariello Research Assistant
  • Dr Clare Lewis Research Assistant
  • Amelia Frizell-Armitage Postgraduate Student
  • Jemima Florence Brinton Postgraduate Student
  • Dr Philippa Borrill Research Fellow
  • Elle Lewis-Smedley Lab Attendant

Awards

2017 - The Royal Agricultural Society of England Research Award

2015 - Personal Promotion BBSRC (Band G)

2014 - Society of Experimental Biology President's Medal Award, 2014

2014 - Honorary Readership, University of East Anglia, UK

2011 - Bayer Early Excellence in Science Award, Bayer Foundation, Leverkusen, Germany

2007 - CGS/UMI Distinguished Dissertation Award, Biological and Life Sciences (awarded every two years to the best dissertation from member Universities in USA and Canada)

2007 - Allen G. Marr Prize Distinguished Dissertation Award, Graduate Studies, UC Davis, CA

2007 - John E. Kinsella Memorial Prize, College of Agric. and Env. Sciences, UC Davis, CA

2007 - Shapiro Family Fund for Excellence in Science Award, Dept. of Plant Sci., UC Davis, CA

2007 - Gerald O. Mott Scholarship for Meritorious Graduate Students in Crop Science (UC Davis), CSSA

2001 - Academic Excellence Award, Pontificia Universidad Católica de Chile (Highest GPA of graduating class)

Media

For media enquiries, contact the John Innes Centre communications team 01603 450962, jic.communications@jic.ac.uk

Media experience: print media and radio interviews (recorded preferred)

Increasing farmers' yields

 

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