Dr Andrew Truman
My research focus is on understanding how structurally complex natural products are constructed by soil-dwelling bacteria.
Genetic, biochemical and chemical techniques are used to determine how molecules with unusual structures are biosynthesised, and we are developing methods to reprogram pathways to produce novel natural product-like molecules. A vast array of medicines are produced by soil-dwelling bacteria, and the discovery of new pathways will support the development of future drugs.
We are examining a variety of natural products, including non-ribosomal peptides like vancomycin, which is a drug of last resort to treat methicillin-resistant Staphylococcus aureus (MRSA) infections, and ribosomally synthesised and post-translationally modified peptides (RiPPs), such as bottromycin. This is a clinically promising and structurally unique RiPP that is active towards multi-drug resistant bacteria, such as MRSA. In addition, the analysis of genomic data has revealed that bacteria have an untapped potential to produce secondary metabolites, and key pathways are being investigated.
Identification and characterisation of the gene cluster for the anti-MRSA antibiotic bottromycin: expanding the biosynthetic diversity of ribosomal peptides
Chemical Science 3 p3516-3521
Publisher’s version: 10.1039/C2SC21190D
Chemistry & Biology 16 p676-685
Publisher’s version: 10.1016/j.chembiol.2009.04.013
The Role of Cep15 in the Biosynthesis of Chloroeremomycin: Reactivation of an Ancestral Catalytic Function
Chemistry & Biology 15 p476-484
Publisher’s version: 10.1016/j.chembiol.2008.03.019
Angewandte Chemie International Edition 55 p96399643
Publisher’s version: 10.1002/anie.201604304
Cyclisation mechanisms in the biosynthesis of ribosomally synthesised and post-translationally modified peptides
Beilstein Journal of Organic Chemistry 12 p1250
Publisher’s version: 10.3762/bjoc.12.120
ACS Chemical Biology 11(8) p2254-2264
Publisher’s version: 10.1021/acschembio.6b00018
The frontline antibiotic vancomycin induces a zinc starvation response in bacteria by binding to Zn(II).
Scientific Reports 6 p19602
Publisher’s version: 10.1038/srep19602
Nature Chemical Biology 11 p625-31
Publisher’s version: 10.1038/nchembio.1890
- Dr Natalia Miguel-Vior Postdoctoral Scientist
- Tom Eyles Postgraduate Student
- Dr Javier Santos Aberturas Postdoctoral Scientist
- Luca Frattaruolo MSc Student
- Dr Thu Pham Research Assistant
- Xunyou Yan Visiting Worker
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