Directory

Dr Andrew Truman

Project Leader
Molecular Microbiology

My research focus is on understanding how structurally complex natural products are constructed by soil-dwelling bacteria. 

Genetic, biochemical and chemical techniques are used to determine how molecules with unusual structures are biosynthesised, and we are developing methods to reprogram pathways to produce novel natural product-like molecules. A vast array of medicines are produced by soil-dwelling bacteria, and the discovery of new pathways will support the development of future drugs.
 
We are examining a variety of natural products, including non-ribosomal peptides like vancomycin, which is a drug of last resort to treat methicillin-resistant Staphylococcus aureus (MRSA) infections, and ribosomally synthesised and post-translationally modified peptides (RiPPs), such as bottromycin. This is a clinically promising and structurally unique RiPP that is active towards multi-drug resistant bacteria, such as MRSA. In addition, the analysis of genomic data has revealed that bacteria have an untapped potential to produce secondary metabolites, and key pathways are being investigated.

Royal Society university research fellow starts at JIC

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Selected Publications

Truman A. W., Dias M. V., Wu S., Blundell T. L., Huang F., Spencer J. B. (2009)

Chimeric glycosyltransferases for the generation of hybrid glycopeptides.

Chemistry & Biology 16 p676-685

Publisher’s version: 10.1016/j.chembiol.2009.04.013

Truman A. W., Fan Q., Röttgen M., Stegmann E., Leadlay P. F., Spencer J. B. (2008)

The Role of Cep15 in the Biosynthesis of Chloroeremomycin: Reactivation of an Ancestral Catalytic Function

Chemistry & Biology 15 p476-484

Publisher’s version: 10.1016/j.chembiol.2008.03.019

Recent Publications

Crone M. J. K., Vior N. M., Santos-Aberturas J., Schmitz L. G., Leeper F. J., Truman A. W. (2016)

Dissecting Bottromycin Biosynthesis Using Comparative Untargeted Metabolomics

Angewandte Chemie International Edition 55 p96399643

Publisher’s version: 10.1002/anie.201604304

Yushchuk O., Ostash B., Pham T. H., Luzhetskyy A., Fedorenko V., Truman A. W., Horbal L. (2016)

Characterization of the Post-Assembly Line Tailoring Processes in Teicoplanin Biosynthesis.

ACS Chemical Biology

Publisher’s version: 10.1021/acschembio.6b00018

Zarkan A., Macklyne H. R., Truman A. W., Hesketh A. R., Hong H. J. (2016)

The frontline antibiotic vancomycin induces a zinc starvation response in bacteria by binding to Zn(II).

Scientific Reports 6 p19602

Publisher’s version: 10.1038/srep19602

Medema M. H., Kottmann R., Yilmaz P., Cummings M., Biggins J. B., Blin K., de Bruijn I., Chooi Y. H., Claesen J., Coates R. C., Cruz-Morales P., Duddela S., Düsterhus S., Edwards D. J., Fewer D. P., Garg N., Geiger C., Gomez-Escribano J. P., Greule A., Hadjithomas M., Haines A. S., Helfrich E. J., Hillwig M. L., Ishida K., Jones A. C., Jones C. S., Jungmann K., Kegler C., Kim H. U., Kötter P., Krug D., Masschelein J., Melnik A. V., Mantovani S. M., Monroe E. A., Moore M., Moss N., Nützmann H. W., Pan G., Pati A., Petras D., Reen F. J., Rosconi F., Rui Z., Tian Z., Tobias N. J., Tsunematsu Y., Wiemann P., Wyckoff E., Yan X., Yim G., Yu F., Xie Y., Aigle B., Apel A. K., Balibar C. J., Balskus E. P., Barona-Gómez F., Bechthold A., Bode H. B., Borriss R., Brady S. F., Brakhage A. A., Caffrey P., Cheng Y. Q., Clardy J., Cox R. J., Donadio S., Donia M. S., van der Donk W. A., Dorrestein P. C., Doyle S., Driessen A. J., Ehling-Schulz M., Entian K. D., Fischbach M. A., Gerwick L., Gerwick W. H., Gross H., Gust B., Hertweck C., Höfte M., Jensen S. E., Ju J., Katz L., Kaysser L., Klassen J. L., Keller N. P., Kormanec J., Kuipers O. P., Kuzuyama T., Kyrpides N. C., Kwon H. J., Lautru S., Lavigne R., Lee C. Y., Linquan B., Liu X., Liu W., Luzhetskyy A., Mahmud T., Mast Y., Méndez C., Metsä-Ketelä M., Micklefield J., Mitchell D. A., Moore B. S., Moreira L. M., Müller R., Neilan B. A., Nett M., Nielsen J., O'Gara F., Oikawa H., Osbourn A., Osburne M. S., Ostash B., Payne S. M., Pernodet J. L., Petricek M., Piel J., Ploux O., Raaijmakers J. M., Salas J. A., Schmitt E. K., Scott B., Seipke R. F., Shen B., Sherman D. H., Sivonen K., Smanski M. J., Sosio M., Stegmann E., Süssmuth R. D., Tahlan K., Thomas C. M., Tang Y., Truman A. W., Viaud M., Walton J. D., Walsh C. T., Weber T., van Wezel G. P., Wilkinson B., Willey J. M., Wohlleben W., Wright G. D., Ziemert N., Zhang C., Zotchev S. B., Breitling R., Takano E., Glöckner F. O. (2015)

Minimum Information about a Biosynthetic Gene cluster

Nature Chemical Biology 11 p625-31

Publisher’s version: 10.1038/nchembio.1890

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Andrew Truman

  • Dr Natalia Miguel-Vior Postdoctoral Scientist
  • Tom Eyles Postgraduate Student
  • Dr Javier Santos Aberturas Postdoctoral Scientist
  • Luca Frattaruolo MSc Student
  • Dr Thu Pham Research Assistant
  • Xunyou Yan Visiting Worker

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