Bacteria make a remarkable array of natural products with potent biological activities.
Many of these molecules have important medicinal and agricultural applications, including antibiotics, antifungals and anti-cancer agents. For example, over two-thirds of clinically used classes of antibiotic are made by the actinomycetes, which are filamentous bacteria commonly found in the soil and associated with plants.
An understanding of the biosynthesis of these molecules can inform the discovery of new natural products with clinically-promising activities, such as antibiotics active towards multidrug-resistant bacteria or new anti-cancer agents.
Research in the Truman group is focused on three interrelated research areas:
Eyles T. H., Vior N. M., Truman A. W.Rapid and robust yeast-mediated pathway refactoring generates multiple new bottromycin-related metabolites.ACS Synthetic Biology (7)Publisher's version: 10.1021/acssynbio.8b00038
Vior N. M., Lacret R., Chandra G., Dorai-Raj S., Trick M., Truman A. W.Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes.Applied and Environmental MicrobiologyPublisher's version: 10.1128/AEM.02828-17
Leipoldt F., Santos-Aberturas J., Stegmann D. P., Wolf F., Kulik A., Lacret R., Popadic D., Keinhörster D., Kirchner N., Bekiesch P., Gross H., Truman A., Kaysser L.Warhead biosynthesis and the origin of structural diversity in hydroxamate metalloproteinase inhibitors.Nature Communications (8)Publisher's version: 10.1038/s41467-017-01975-6
Informal enquiries to join the group from interested Postgraduate and Postdoctoral Scientists are always welcomed.