Postdoctoral Researcher (Sablowski Group)

An exciting opportunity has arisen for a Postdoctoral Researcher to join the Sablowski Group at the John Innes Centre, working on cutting-edge science in the field of Cell and Developmental Biology.

About the Sablowski Group

The Sablowski lab works on the genetics and cell biology of meristem and early organ development in the model plant species, Arabidopsis thaliana. The team is relatively small (5-6 members), collaborative and led by a supervisor who is active at the bench. Reflecting the quality of their research and training, more than half of the postdocs who worked in the team moved up to long-term research positions in academia or industry.

Recent work in the group has focused on the genetic control of cell size. From bacteria to humans, cell size is important for many processes, including exchange of nutrients and signals, cell division and the function of specialized cells. However, how cells achieve and maintain their genetically controlled size has been a longstanding mystery. The Sablowski team has recently shown that in meristem cells, DNA content is used as a reference to adjust cell cycle progression to cell size (doi:10.1126/science.abb4348).

The aims of the next phase of this project include identifying protein-chromatin interactions at the core of the cell size control mechanism, revealing how cell size control is linked to cell fate decisions, testing whether the mechanism explains why cell size correlates with genome size, and whether cell size control has been re-calibrated during the evolution of polyploid plants.

The role

The successful applicant will investigate how cell size and cell fate are linked during plant development. Within this broad aim, the post holder will design, execute, and interpret experiments to test initial hypotheses defined in the project, then propose and test their own hypotheses, informed by results.

The ideal candidate

You will have a PhD (full award or expected within 6 months) or equivalent in molecular biology, cell biology or a related discipline. The ideal candidate will have a rigorous, analytical, and creative mind, passion for curiosity-driven science and research experience in cell biology and/or developmental genetics. Proficiency in molecular biology and bioimaging is required; experience in Arabidopsis genetics and coding (particularly in Python) will be advantageous.

Additional information

Interviews will be held on 10 January 2023.

Further information and details of how to apply can be found here, or contact the Human Resources team on 01603 450814 or quoting reference 1004365.

We are an equal opportunities employer, actively supporting inclusivity and diversity.  As a Disability Confident organisation, we guarantee to offer an interview to all disabled applicants who meet the essential criteria for this vacancy. We are proud to hold a prestigious Gold Athena SWAN award in recognition of our inclusive culture, commitment and good practices towards advancing of gender equality. We offer an exciting, stimulating, diverse research environment and actively promote a family friendly workplace. The Institute is also a member of Stonewall’s Diversity Champions programme.

The John Innes Centre is a registered charity (No. 223852) grant-aided by the Biotechnology and Biological Sciences Research Council.

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