Applications are invited for a Postdoctoral Researcher to join the group of Prof Martin Howard in the Department of Computational and Systems Biology at the John Innes Centre, Norwich, UK.

About the Howard Group

The Howard group combines simple, predictive mathematical and biophysical modelling with long-lasting experimental collaborations to dissect biological mechanisms too complex to unravel by experiments alone. In many cases we are able to rationalise complex biological dynamics into simple underlying mechanisms, with few components and interactions.

Our approach is highly interdisciplinary and relies heavily on the techniques of statistical physics and applied mathematics, as well as on close collaboration with experimental groups. At present there are two main research areas in the group: understanding patterning dynamics in sub-cellular biological systems and probing how epigenetic memory states are set up and then stably maintained. For patterning, the main application at present is to the dynamics of crossover positioning in meiosis, understanding how crossovers are rarely closely positioned in space, an intriguing phenomenon called crossover interference. For epigenetics, we work on both histone modification memory systems, as well as on DNA methylation.

The group regularly publishes in the most prominent multidisciplinary journals, with recent papers in Nature, Science, Cell Systems, eLife, Molecular Cell and PNAS. Several previous members of the Howard group now hold independent faculty positions of their own, including in Warwick, Glasgow, Sydney, Amsterdam and Munich.

The role

The main purpose of the position is to develop computational models of meiotic crossover patterning, collaborating with the experimental group of Dr Chris Morgan also at the John Innes Centre. The models will enhance our understanding of how crossovers are positioned, using phase-separating coarsening dynamics. The position would suit an individual with a high degree of independence and vision, able to advance the project independently. The successful candidate will have a rare opportunity to work on fundamental biological processes in a truly interdisciplinary environment, with seamless collaboration with a leading experimental group.

The ideal candidate

The ideal candidate will possess (or soon complete) a PhD in Theoretical Physics, Bio-Mathematics or Computational Biology. They will possess a strong interest in biological problems and have achieved demonstrable scientific success in previous roles. Prior experience of biological modelling is desirable but not essential.

Additional information

Further information and details of how to apply can be found here, or contact the Human Resources team on 01603 450814 or nbi.recruitment@nbi.ac.uk quoting reference 1004815.

This role meets the criteria for a visa application, all visa costs will be covered, and we encourage all qualified candidates to apply. Please contact the Human Resources Team if you have any questions regarding your application or visa options.

Interviews will be held on 12 March 2025.

We are an equal opportunities employer, actively supporting inclusivity and diversity.  As a Disability Confident organisation, we guarantee to offer an interview to all disabled applicants who meet the essential criteria for this vacancy. We are proud to hold a prestigious Gold Athena SWAN award in recognition of our inclusive culture, commitment and good practices towards advancing of gender equality. We offer an exciting, stimulating, diverse research environment and actively promote a family friendly workplace. The Institute is also a member of Stonewall’s Diversity Champions programme.

The John Innes Centre is a registered charity (No. 223852) grant-aided by the Biotechnology and Biological Sciences Research Council.

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