At the John Innes Centre we have a range of technologies to structually analyse molecules, genomes and commercially valuable compounds.
Our molecular analysis service provides analytical support for all John Innes Centre science that is concerned with the chemical make-up of plants and microbes; studying novel compounds, measuring amounts of important chemicals and studying the proteins that are the building-blocks of life.
We use X-ray crystallography to reveal the atomic details of biological systems, providing deep insights into molecular interactions, gene regulation, enzyme mechanism, protein function and protein evolution.
The protein crystallography platform provides facilities and expertise to help determine the 3D structure of proteins starting from a purified sample.
Nuclear Magnetic Resonance Spectroscopy allows structural analysis of new compounds, metabolite identification, monitoring enzymatic reactions and understanding enzyme specificity and mode of action.
Finally, our Proteomics Facility provides services in the area of proteomics using mass spectrometry. The facility is equipped with four state-of-the-art mass spectrometers covering a wide range of applications. This allows for a broad range of methods including analysis of individual proteins (e.g. intact mass, sequencing, identification), the qualitative and quantitative analysis of complex protein samples (e.g. pull-downs, expression studies, modifications, isotope labelling), as well as mass spectrometry imaging and ion mobility.