How phytoplasmas generate witches' brooms and attract insect vectors


Functional genomics of how insects manipulate plants


View all publications from the Hogenhout Lab


Vincent TR, Canham J, Toyota M, Avramova M, Mugford ST, Gilroy S, Miller AJ, Hogenhout S, Sanders D. Real-time In Vivo Recording of Arabidopsis Calcium Signals During Insect Feeding Using a Fluorescent Biosensor. J Vis Exp. 2017 Aug 15;(126). doi: 10.3791/56142. PMID: 28829425

Vincent TR, Avramova M, Canham J, Higgins P, Bilkey N, Mugford ST, Pitino M, Toyota M, Gilroy S, Miller AJ, Hogenhout SA, Sanders D. Interplay of Plasma Membrane and Vacuolar Ion Channels, Together with BAK1, Elicits Rapid Cytosolic Calcium Elevations in Arabidopsis during Aphid Feeding. Plant Cell. 2017 Jun;29(6):1460-1479. doi: 10.1105/tpc.17.00136. Epub 2017 May 30. PMID: 28559475

Mathers TC, Chen Y, Kaithakottil G, Legeai F, Mugford ST, Baa-Puyoulet P, Bretaudeau A, Clavijo B, Colella S, Collin O, Dalmay T, Derrien T, Feng H, Gabaldón T, Jordan A, Julca I, Kettles GJ, Kowitwanich K, Lavenier D, Lenzi P, Lopez-Gomollon S, Loska D, Mapleson D, Maumus F, Moxon S, Price DR, Sugio A, van Munster M, Uzest M, Waite D, Jander G, Tagu D, Wilson AC, van Oosterhout C, Swarbreck D, Hogenhout SA. Rapid transcriptional plasticity of duplicated gene clusters enables a clonally reproducing aphid to colonise diverse plant species. Genome Biol. 2017 Feb 13;18(1):27. doi: 10.1186/s13059-016-1145-3. Erratum in: Genome Biol. 2017 Apr 4;18(1):63. PMID: 28190401


Mugford ST, Barclay E, Drurey C, Findlay KC, Hogenhout SA. An Immuno-Suppressive Aphid Saliva Protein Is Delivered into the Cytosol of Plant Mesophyll Cells During Feeding. Mol Plant Microbe Interact. 2016 Nov;29(11):854-861. Epub 2016 Nov 10. PMID: 27831211

Coleman, A. D., Mugford, S. T., & Hogenhout, S. A. (2016). Silencing of aphid genes by dsRNA feeding from plants. In Management of Insect Pests to Agriculture (pp. 245-251). Springer International Publishing.


Coleman AD, Wouters RHM, Mugford ST and Hogenhout SA (2015) Persistence and transgenerational effect of plant-mediated RNAi in aphids. Journal of Experimental Botany 66; 541-548.



Rodriguez PA, Hogenhout SA, Bos JI. (2014) Leaf-Disc Assay Based on Transient Over-Expression in Nicotiana benthamiana to Allow Functional Screening of Candidate Effectors from Aphids. Methods Mol Biol. 2014;1127:137-43. doi: 10.1007/978-1-62703-986-4_11. PubMed PMID: 24643558.

Coleman AD, Pitino M, Hogenhout SA. (2014) Silencing of Aphid Genes by Feeding on Stable Transgenic Arabidopsis thaliana. Methods Mol Biol. 2014;1127:125-36. doi: 10.1007/978-1-62703-986-4_10. PubMed PMID: 24643557.

Prince DC, Drurey C, Zipfel C, Hogenhout SA. (2014) The Leucine-Rich Repeat Receptor-Like Kinase BRASSINOSTEROID INSENSITIVE1-ASSOCIATED KINASE1 and the Cytochrome P450 PHYTOALEXIN DEFICIENT3 Contribute to Innate Immunity to Aphids in Arabidopsis. Plant Physiol. 2014 Apr;164(4):2207-19. doi: 10.1104/pp.114.235598. Epub 2014 Feb 28. PubMed PMID: 24586042.



Kettles G., Drurey C., Schoonbeek H-j., Maule A. J. and Hogenhout S. A. (2013). Resistance of Arabidopsis thaliana to the green peach aphid, Myzus persicae, involves camalexin and is regulated by microRNAs. New Phytologist 198:1178-1190.

Pitino M. and Hogenhout S. A. (2013). Aphid Protein Effectors Promote Aphid Colonization in a Plant Species-Specific Manner. Mol. Plant-Microbe Interact. 26: 130-139.



Bos J. I. B. and Hogenhout S. A. (2011). Effectors in Plant-Insect Interactions. In: Effectors in Plant-Microbe Interactions (Martin F. and Kamoun S. eds). Wiley & Sons, Ltd., Chichester, UK, Pp. 355-376.

Pitino M., Coleman A. D., Maffei M., Ridout C. J. and Hogenhout S. A. (2011). Silencing of aphid genes by dsRNA feeding from plants. PLoS One 6: e25709 (Faculty of 1000 rated; 3x).

Bos J.I.B. and Hogenhout S. A. (2011). Effector proteins that modulate plant-insect interactions. Curr. Opin. Plant Biol. 14: 1-7.



Bos J.I.B., Prince D., Pitino M., Maffei M. E., Win J. and Hogenhout S. A. (2010). A functional genomics approach identifies candidate effectors from the aphid species Myzus persicae. PLoS Genetics 6: e1001216.



Hogenhout S. A., Ammar E-D., Whitfield, A. E. and Redinbaugh M. G. (2008). Insect Vector Interactions with Persistently Transmitted Viruses. Annu. Rev. Phytopathol. 46: 327-359.



Hogenhout S.A., Verbeek M., Van der Wilk F., Goldbach R.W. and Van den Heuvel J.F.J.M. (2000). Identifying the determinants in the equatorial domain of Buchnera GroEL implicated in binding Potato leafroll virus. J. Virol. 74: 4541-4548.



Van den Heuvel J.F.J.M., Hogenhout S.A., and Van der Wilk F. (1999). Recognition and receptors in virus transmission by arthropods. Trends Microbiol. 7: 71-76



Van den Heuvel J.F.J.M., Hogenhout S.A., Verbeek M. and Van der Wilk F. (1998). Azadirachta indica metabolites interfere with the host-endosymbiont relationship and inhibit the transmission of potato leafroll virus by Myzus persicae. Entomol. Exp. Appl. 86: 260-263.

Hogenhout S.A., van der Wilk F., Verbeek M., Goldbach R.W. and Van den Heuvel J.F.J.M. (1998). Potato leafroll virus binds to the equatorial domain of the aphid endosymbiotic GroEL homolog. J. Virol. 72: 358-365.



Van den Heuvel J.F.J.M., Bruyère A., Hogenhout S.A., Ziegler-Graff V., Brault V., Verbeek M., Van der Wilk F. and Richards K. (1997). The N-terminal region of the Luteovirus readthrough domain determines virus binding to Buchnera GroEL and is essential for virus persistence in the aphid. J. Virol. 71: 7258-7265.



Hogenhout S. A., Verbeek M., Hans F., Houterman P.M., Fortass M., van der Wilk F., Huttinga H. and J.F.J.M. van den Heuvel (1996). Molecular basis of the interaction between luteoviruses and aphids. Agronomie 16: 167-173.