COMPUTATIONAL MODELLING

We are collaborating with Prof. Martin Howard, (Computational and Systems Biology, John Innes Centre) to model both vernalization and the autonomous pathway.

With ERC funding we are modelling the chromatin dynamics regulating the epigenetic silencing of FLC by prolonged cold.

We are also exploring the thermosensory inputs in this mechanism to understand how plants integrate complex temperature profiles over weeks and months.

Modelling of the consequences of the polymorphism conferring natural variation in FLC silencing, namely requirement for longer winter, has enabled us to determine which aspects of the Polycomb mechanism are attenuated.

We are also addressing whether quantitative changes in FLC expression in ambient temperatures occurs through regulation of co-transcriptional processing linked to chromatin changes via a bistable, cell-autonomous switch or a quantitative rheostat mechanism.