Thomas is interested in DNA topoisomerases, which are essential and ubiquitous enzymes involved in the regulation of genome topology and stability.
These enzymes are important target for antitumoral and antibacterial drugs and his research focuses on their mechanism of action and the roles of DNA topoisomerases in the bacterial and eukaryotic cell.
Kolaric A,Germe T,Hrast M,Stevenson CEM,Lawson DM,Burton NP,Vörös J,Maxwell T,Minovski N,Anderluh M (2021)Potent DNA gyrase inhibitors bind asymmetrically to their target using symmetrical bifurcated halogen bonds.Nature communicationsPublisher's version: 2041-1723
Bax B. D., Murshudov G., Maxwell A., Germe T. (2019)DNA Topoisomerase Inhibitors: Trapping a DNA-Cleaving Machine in Motion.Journal of Molecular BiologyPublisher's version: 0022-2836
Germe T., Voros J., Jeannot F., Taillier T., Stavenger R. A., Bacqué E., Maxwell A., Bax B. D. (2018)A new class of antibacterials, the imidazopyrazinones, reveal structural transitions involved in DNA gyrase poisoning and mechanisms of resistance.Nucleic acids researchPublisher's version: 0305-1048