Nidda’s research falls within the main research theme of the Maxwell group, the study of a group of enzymes known as DNA topoisomerases.
The topoisomerases are essential enzymes that function to regulate the topological state of DNA. The first topoisomerase to be classified in bacteria, DNA gyrase, has been the subject of thorough scientific investigation. Consequently, DNA gyrase has been identified to be a well-established drug target for the wide spectrum quinolone antibiotics.
More recently, DNA gyrase has also been identified in eukaryotic species, including plants and plasmodial parasites.
Nidda’s research is focused on studying the eukaryotic DNA gyrase protein, in the wider context of aiding to develop this enzyme as a herbicidal or anti-malarial drug target.
Her current work involves heterologous expression of these proteins, characterisation and inhibitor screening.
Wallace M. D., Waraich N. F., Debowski A. W., Corral M. G., Maxwell T., Mylne J. S., Stubbs K. A. (2018)Developing ciprofloxacin analogues against plant DNA gyrase: a novel herbicide mode of action.Chemical Communications (54)Publisher's version: 1359-7345
Bush N. G., Agarwal M., Henderson S. R., Waraich N. F., Maxwell A. (2018)DNA in a twist? How topoisomerases solve topological problems in DNAThe Biochemist (April)