Monica is interested in understanding and exploiting the role of type II DNA topoisomerases in DNA replication and recombination.
Her focus is on the type IIB subfamily of topoisomerase, which includes topoisomerase VI.
Although originally identified in archaea, recently its homologs have been identified in the eukaryotes, including Arabidopsis thaliana and Plasmodium species.
Monica’s current work involves the expression and characterisation of topoisomerase VI from Arabidopsis and Plasmodium, which will help in understanding the functional aspects.
Topoisomerase VI enzymes are a novel target for herbicides and antimalarial drugs and her research focuses on their mechanism of action and inhibitors screening.