Lauren Abbott

Year in Industry Student Molecules from Nature

Topoisomerase enzymes are found in all cellular organisms and are essential for the maintenance of genome structures by regulation of DNA topology.

The presence and variation of these crucial enzymes between eukaryotes and prokaryotes makes them significant therapeutic targets.

DNA gyrase and DNA topoisomerase IV are bacterial type IIA topoisomerases and the targets of antibacterials such as the fluoro-quinolones (FQs).

Lauren’s project addresses the increasing threat of anti-bacterial resistance (such as FQ resistance), by screening and investigating a range of compounds against bacterial DNA gyrase and DNA topo IV.