James is interested in the mechanisms that control gene regulation during development and how these mechanisms have evolved in plants.
His current work involves a DNA methylation pathway that regularly targets transposons. In the sex cells of Arabidopsis thaliana it has been found to also target genes and effects their expression as well as splicing.
James also interested in comparing the DNA methylation profiles during the development of other species across the plant kingdom
Walker J., Gao H., Zhang J., Aldridge B., Vickers M., Higgins J., Feng X. (2018)Sexual-lineage-specific DNA methylation regulates meiosis in Arabidopsis.Nature Genetics (50)Publisher's version: 1061-4036