In her work, Eva uses plants as biofactories for the production of target proteins.
Her focus is mainly on the structural proteins of viruses which are of medical or veterinary importance, such as Bluetongue virus, Hepatitis B or Zika virus.
When produced by the plant, such proteins can assemble into structures called virus-like particles which resemble the virus but do not contain viral nucleic acid, the information needed to cause an infection.
Such particles are safe to handle and can be used to develop diagnostics, study virus structure, or to make vaccines.
Thuenemann E. C., Lomonossoff G. P. (2018)Delivering Cargo: Plant-Based Production of Bluetongue Virus Core-Like and Virus-Like Particles Containing Fluorescent Proteins.Publisher's version: 1064-3745
Thuenemann E. C., Meyers A. E., Verwey J., Rybicki E. P., Lomonossoff G. P. (2013)A method for rapid production of heteromultimeric protein complexes in plants: assembly of protective bluetongue virus-like particles.Plant Biotechnology Journal (11)Publisher's version: 1467-7644
Sainsbury F., Thuenemann E. C., Lomonossoff G. P. (2009)pEAQ: versatile expression vectors for easy and quick transient expression of heterologous proteins in plantsPlant Biotechnology Journal (7)