Dr Eduardo Mateo-Bonmati

Postdoctoral Scientist Genes in the Environment

RNA-mediated chromatin regulation is central for gene expression in many organisms, including plants, but how RNA influence chromatin environments is poorly understood.

The Arabidopsis thaliana floral repressor FLOWERING LOCUS C (FLC) transcription is quantitatively regulated by COOLAIR, a set of long non-coding antisense transcripts. This regulation is mediated by a set of genes grouped into de autonomous pathway, which have general transcriptional functions in the Arabidopsis genome.

FCA, one of the autonomous pathway members, mediates proximal 3’end processing of COOLAIR and that allows the FLD/SDG26/LD complex to remove H3K4me1 from FLC to transcriptionally silence the gene. By means of different genetic and molecular tools, Eduardo is investigating how 3’ end processing links to FLD complex at FLC.