Thomas is interested in DNA topoisomerases, which are essential and ubiquitous enzymes involved in the regulation of genome topology and stability.
These enzymes are important target for antitumoral and antibacterial drugs and his research focuses on their mechanism of action and the roles of DNA topoisomerases in the bacterial and eukaryotic cell.
Germe T., Voros J., Jeannot F., Taillier T., Stavenger R. A., Bacqué E., Maxwell A., Bax B. D. (2018)A new class of antibacterials, the imidazopyrazinones, reveal structural transitions involved in DNA gyrase poisoning and mechanisms of resistance.Nucleic acids researchPublisher's version: 0305-1048
Chan P. F., Germe T., Bax B. D., Huang J., Thalji R. K., Bacqué E., Checchia A., Chen D., Cui H., Ding X., Ingraham K., McCloskey L., Raha K., Srikannathasan V., Maxwell A., Stavenger R. A. (2017)Thiophene antibacterials that allosterically stabilize DNA-cleavage complexes with DNA gyrase.Proceedings of the National Academy of Sciences of the United States of America (Early Edition 15 may 2017)Publisher's version: 0027-8424