Dr Stan Maree
Computational and Systems Biology
Since we have entered the era of bioinformatics, we continuously gain a better understanding of the processes that take place at the subcellular level. However, there is limited knowledge on how the subcellular processes eventually lead to morphogenesis, how during embryogenesis tissues, organs, whole organisms emerge and are able to grow, develop, and maintain themselves.
To bridge the gap, we are using multi-level modelling approaches, in which all the pre-defined dynamics in the models are on the (sub)cellular level, while all the interesting behaviour that emerges from the models take place at different levels of organisation, from the level of the tissue to the level of the organism.
To do so, we combine gene regulatory networks with biophysics and morphogen dynamics.
In close collaboration with experimental groups we then challenge old experiments and inspire new ones, to unravel the complexity of the the observed development. Moreover, by comparing and contrasting different systems in different kingdoms, from Arabidopsis to chick development, from root to fruit, we try to derive general principles driving development but also how they specifically operate in a particular system.
ContactTel: 01603 450828
Tissue Dimensionality Influences the Functional Response of Cytotoxic T Lymphocyte-Mediated Killing of Targets.
Frontiers in immunology 7 p668
Publisher’s version: 10.3389/fimmu.2016.00668
eLife 5 p1-43
Publisher’s version: 10.7554/eLife.18165
Parsimonious Model of Vascular Patterning Links Transverse Hormone Fluxes to Lateral Root Initiation: Auxin Leads the Way, while Cytokinin Levels Out.
PLoS Computational Biology 11 pe1004450
Publisher’s version: 10.1371/journal.pcbi.1004450
Plant Physiology 169 p194-208
Publisher’s version: 10.1104/pp.15.00343
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