Dr Stan Maree

Project Leader
Computational and Systems Biology

Stan uses computational and mathematical techniques to investigate biological problems from the subcellular through to the ecological scale. Such multi-level modelling allows Stan to explain, for example, hormonal influences on tissue growth or the spread of vector-borne disease through crop fields.

Stan uses modelling techniques to develop novel theories and to suggest mechanisms that explain biological problems. He teams up with experimental scientists to test and modify these theories until they accurately explain the observed data.

  • Mathematical and computational modelling
  • Solving biological problems from the subcellular to the ecological scale
  • Data analysis and software development for biological data

 

Since we have entered the era of bioinformatics, we continuously gain a better understanding of the processes that take place at the subcellular level. However, there is limited knowledge on how the subcellular processes eventually lead to morphogenesis, how during embryogenesis tissues, organs, whole organisms emerge and are able to grow, develop, and maintain themselves.

To bridge the gap, the group are using multi-level modelling approaches, in which all the pre-defined dynamics in the models are on the (sub)cellular level, while all the interesting behaviour that emerges from the models take place at different levels of organisation, from the level of the tissue to the level of the organism.

To do so, they combine gene regulatory networks with biophysics and morphogen dynamics.

In close collaboration with experimental groups the group then challenge old experiments and inspire new ones, to unravel the complexity of the the observed development. Moreover, by comparing and contrasting different systems in different kingdoms, from Arabidopsis to chick development, from root to fruit, we try to derive general principles driving development but also how they specifically operate in a particular system.

Contact

Tel: 01603 450828
stan.maree@jic.ac.uk

Sound new technique tunes into the shifting shapes of biology

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Life in the fast lane: how plants avoid traffic jams

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Hormonal tug-of-war helps plant roots navigate their journey through the soil, new international study finds

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Recent Publications

Tomkins M., Kliot A., Maree A. F. M., Hogenhout S. A. (2018)

A multi-layered mechanistic modelling approach to understand how effector genes extend beyond phytoplasma to modulate plant hosts, insect vectors and the environment.

Current Opinion in Plant Biology 44 p39-48

Publisher’s version: 10.1016/j.pbi.2018.02.002

Sanchez-Corrales Y. E., Hartley M., van Rooij J., Maree A. F. M., Grieneisen V. A. (2018)

Morphometrics of complex cell shapes: Lobe Contribution Elliptic Fourier Analysis (LOCO-EFA).

Development (Cambridge, England)

Publisher’s version: 10.1242/dev.156778

Carter R., Sánchez-Corrales Y. E., Hartley M., Grieneisen V., Marée A. F. M. (2017)

Pavement cells and the topology puzzle.

Development (Cambridge, England) 144 p4386-4397

Publisher’s version: 10.1242/dev.157073

Mambro R. D., De Ruvo M., Pacifici E., Salvi E., Sozzani R., Benfey P. H., Busch W., Novak O., Ljung K., Di Paola L., Maree A. F. M., Costantino P., Grieneisen V. A., Sabatini S. (2017)

Auxin minimum triggers the developmental switch from cell division to cell differentiation in the Arabidopsis root.

Proceedings of the National Academy of Sciences of the United States of America 114 pE7641-E7649

Publisher’s version: 10.1073/pnas.1705833114

Sotta N., Duncan S., Tanaka M., Sato T., Maree A. F. M., Fujiwara T., Grieneisen V. A. (2017)

Rapid transporter regulation prevents substrate flow traffic jams in boron transport.

eLife 6

Publisher’s version: 10.7554/eLife.27038

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Media

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