Prof Rob Field

Project Leader
Biological Chemistry

Carbohydrates play many and varied roles in biology, contributing as energy sources, structural materials, binding and signalling molecules. In contrast to nucleic acids and proteins, carbohydrates are not template-encoded, which adds enormously to the diversity of carbohydrate structures that may be produced and imparts huge complexity to their analysis and definition of their biological function.

Research in the Field group is focused on developing and exploiting chemical tools and principles to address questions in plant and microbial carbohydrate metabolism. Projects typically involve some combination of chemical and enzymatic synthesis, inhibitor design and assessment, biochemistry, structural biology, metabolomic, proteomic and transcriptomic analysis. From a biology perspective, we work cross-Kingdom: Arabidopsis, barley, Euglena, Streptomyces, E. coli, flu virus, the African and American trypanosome.

Contact

Tel: 01603 450720
rob.field@jic.ac.uk

Anglers’ delight as algal blooms breakthrough highlights innovative science

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Norwich scientists win international award in bid to solve antibiotic resistance

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The potential in your pond

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Rapid flu test project shortlisted to win Royal Society of Chemistry Competition

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Recent Publications

Rugen M. D., Andriotis V. M. E., Field R. A. (2017)

Small-Molecule Probes of Plant Glycopolymer Metabolism

Publisher’s version: 10.1016/B978-0-12-409547- 2.12657-5

Ndhen D., Rogowski A., Cartmell A., Luis A. S., Baslé A., Gray J., Venditto I., Briggs J., Zhang X., Labourel A., Terrapon N., Buffetto F., Nepogodiev S., Xiao Y., Field R. A., Zhu Y., O'Neill M. A., Urbanowicz B. R., York W. S., Davies G. J., Abbott D. W., Ralet M. C., Martens E. C., Henrissat B., Gilbert H. J. (2017)

Complex pectin metabolism by gut bacteria reveals novel catalytic functions.

Nature 544 p65-70

Publisher’s version: 10.1038/nature21725

Wagstaff B. A., Vladu I. C., Barclay J. E., Schroeder D. C., Malin G., Field R. A. (2017)

Isolation and Characterization of a Double Stranded DNA Megavirus Infecting the Toxin-Producing Haptophyte Prymnesium parvum.

Viruses 9 p40

Publisher’s version: 10.3390/v9030040

Møller S. R., Yi X., Velásquez S. M., Gille S., Hansen P. L., Poulsen C. P., Olsen C. E., Rejzek M., Parsons H., Zhang Y., Wandall H. H., Clausen H., Field R. A., Pauly M., Estevez J. M., Harholt J., Ulvskov P., Petersen B. L. (2017)

Identification and evolution of a plant cell wall specific glycoprotein glycosyl transferase, ExAD.

Scientific reports 7 p45341

Publisher’s version: 10.1038/srep45341

Ivanova I. M., Nepogodiev S. A., Saalbach G., O'Neill E. C., Urbaniak M. D., Ferguson M. A. J., Gurcha S. S., Besra G. S., Field R. A. (2017)

Fluorescent mannosides serve as acceptor substrates for glycosyltransferase and sugar-1-phosphate transferase activities in Euglena gracilis membranes

Carbohydrate Research 438 p26-38

Publisher’s version: 10.1016/j.carres.2016.11.017

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Rob Field

Media

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