Prof Rob Field

Project Leader
Biological Chemistry

Rob’s research focuses on carbohydrate chemistry and biochemistry.

He develops chemical probes and uses gene manipulation to impact carbohydrate biosynthesis and degradation pathways, thereby generating new products.

Rob’s research spans a broad range of organisms including plants, algae, bacteria and viruses. This work has resulted in a number of applications, from designer carbohydrates for functional food studies to developing diagnostics for infectious diseases.

  • Chemical and enzymatic synthesis
  • Small molecule probes
  • Glycobiology across a broad range of species

 

Carbohydrates play many and varied roles in biology, contributing as energy sources, structural materials, binding and signalling molecules. In contrast to nucleic acids and proteins, carbohydrates are not template-encoded, which adds enormously to the diversity of carbohydrate structures that may be produced and imparts huge complexity to their analysis and definition of their biological function.

Research in the Field group is focused on developing and exploiting chemical tools and principles to address questions in plant and microbial carbohydrate metabolism. Projects typically involve some combination of chemical and enzymatic synthesis, inhibitor design and assessment, biochemistry, structural biology, metabolomic, proteomic and transcriptomic analysis.

From a biology perspective, the lab work cross-Kingdom: Arabidopsis, barley, Euglena, Streptomyces, E. coli, flu virus, the African and American trypanosome.

Contact

Tel: 01603 450720
rob.field@jic.ac.uk

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Recent Publications

Bayliss M., Donaldson M. I., Nepogodiev S. A., Pergolizzi G., Scott A. E., Harmer N. J., Field R. A., Prior J. L. (2017)

Structural characterisation of the capsular polysaccharide expressed by Burkholderia thailandensis strain E555:: wbiI (pKnock-KmR) and assessment of the significance of the 2-O-acetyl group in immune protection.

Carbohydrate Research 452 p17-24

Publisher’s version: 10.1016/j.carres.2017.09.011

Rugen M. D., Andriotis V. M. E., Field R. A. (2017)

Small-Molecule Probes of Plant Glycopolymer Metabolism

Publisher’s version: 10.1016/B978-0-12-409547- 2.12657-5

Ndhen D., Rogowski A., Cartmell A., Luis A. S., Baslé A., Gray J., Venditto I., Briggs J., Zhang X., Labourel A., Terrapon N., Buffetto F., Nepogodiev S., Xiao Y., Field R. A., Zhu Y., O'Neill M. A., Urbanowicz B. R., York W. S., Davies G. J., Abbott D. W., Ralet M. C., Martens E. C., Henrissat B., Gilbert H. J. (2017)

Complex pectin metabolism by gut bacteria reveals novel catalytic functions.

Nature 544 p65-70

Publisher’s version: 10.1038/nature21725

Wagstaff B. A., Vladu I. C., Barclay J. E., Schroeder D. C., Malin G., Field R. A. (2017)

Isolation and Characterization of a Double Stranded DNA Megavirus Infecting the Toxin-Producing Haptophyte Prymnesium parvum.

Viruses 9 p40

Publisher’s version: 10.3390/v9030040

Møller S. R., Yi X., Velásquez S. M., Gille S., Hansen P. L., Poulsen C. P., Olsen C. E., Rejzek M., Parsons H., Zhang Y., Wandall H. H., Clausen H., Field R. A., Pauly M., Estevez J. M., Harholt J., Ulvskov P., Petersen B. L. (2017)

Identification and evolution of a plant cell wall specific glycoprotein glycosyl transferase, ExAD.

Scientific reports 7 p45341

Publisher’s version: 10.1038/srep45341

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Rob Field

Media

For media enquiries, please contact the JIC communications team 01603 450962, jic.communications@jic.ac.uk

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