Prof Rob Field
Rob’s research focuses on carbohydrate chemistry and biochemistry.
He develops chemical probes and uses gene manipulation to impact carbohydrate biosynthesis and degradation pathways, thereby generating new products.
Rob’s research spans a broad range of organisms including plants, algae, bacteria and viruses. This work has resulted in a number of applications, from designer carbohydrates for functional food studies to developing diagnostics for infectious diseases.
- Chemical and enzymatic synthesis
- Small molecule probes
- Glycobiology across a broad range of species
Carbohydrates play many and varied roles in biology, contributing as energy sources, structural materials, binding and signalling molecules. In contrast to nucleic acids and proteins, carbohydrates are not template-encoded, which adds enormously to the diversity of carbohydrate structures that may be produced and imparts huge complexity to their analysis and definition of their biological function.
Research in the Field group is focused on developing and exploiting chemical tools and principles to address questions in plant and microbial carbohydrate metabolism. Projects typically involve some combination of chemical and enzymatic synthesis, inhibitor design and assessment, biochemistry, structural biology, metabolomic, proteomic and transcriptomic analysis.
From a biology perspective, the lab work cross-Kingdom: Arabidopsis, barley, Euglena, Streptomyces, E. coli, flu virus, the African and American trypanosome.
ContactTel: 01603 450720
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Structural characterisation of the capsular polysaccharide expressed by Burkholderia thailandensis strain E555:: wbiI (pKnock-KmR) and assessment of the significance of the 2-O-acetyl group in immune protection.
Carbohydrate Research 452 p17-24
Publisher’s version: 10.1016/j.carres.2017.09.011
Publisher’s version: 10.1016/B978-0-12-409547- 2.12657-5
Nature 544 p65-70
Publisher’s version: 10.1038/nature21725
Isolation and Characterization of a Double Stranded DNA Megavirus Infecting the Toxin-Producing Haptophyte Prymnesium parvum.
Viruses 9 p40
Publisher’s version: 10.3390/v9030040
Scientific reports 7 p45341
Publisher’s version: 10.1038/srep45341
- Maria Marin Altaba Visiting Worker
- Sakonwan Kuhaudomlarp Postgraduate Student
- Dr Simone Dedola Research Assistant
- Lucky Gu Bin Visiting Worker
- Edward Hems Postgraduate Student
- Rebecca Winsbury Postgraduate Student
- Ben Wagstaff Postgraduate Student
- Dr Gerhard Saalbach Senior Scientist
- Dr Mike Rugen Postgraduate Student
- Dr Martin Rejzek Research Assistant
- Dr Sergey Nepogodiev Research Assistant
- Dr Giulia Pergolizzi Postdoctoral Scientist
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