Dr Mike Rugen
I am an ERA-CAPS funded post-doctoral research scientist working on a collaborative project with the aim of better understanding starch synthesis within plants and reconstituting this pathway within heterologous organisms. My research centres on the use of in vitro biochemical analysis and chemical biology to understand the enzymes involved in starch and other carbohydrate metabolism within plant systems.
Starch is one of the most abundant biopolymers and constitutes the main sources of energy for mankind, as well as having industrial and economic impact as both bulk commodities and added value products. My work complements collaborative synthetic biology (Zeeman lab, ETH, Zurich) and mathematical computational modelling (Ebenhoeh lab, Heinrich Heine University, Dusseldorf) projects working towards a better understanding and therefore manipulation of starch and alpha-glucan structure.
Publisher’s version: 10.1016/B978-0-12-409547- 2.12657-5
Scientific reports 6 p33215
Publisher’s version: 10.1038/srep33215
CuAAC click chemistry with N-propargyl 1,5-dideoxy-1,5-imino-D-gulitol and N-propargyl 1,6-dideoxy-1,6-imino-D-mannitol provides access to triazole-linked piperidine and azepane pseudo-disaccharide iminosugars displaying glycosidase inhibitory properties.
Carbohydrate Research 429 p29-37
Publisher’s version: 10.1016/j.carres.2016.04.020
Iminosugar inhibitors of carbohydrate-active enzymes that underpin cereal grain germination and endosperm metabolism.
Biochemical Society Transactions 44 p159-165
Publisher’s version: 10.1042/BST20150222