Dr Mike Rugen

Postdoctoral Scientist
Biological Chemistry

Mike is an ERA-CAPS funded postdoctoral research scientist working on a collaborative project with the aim of better understanding starch synthesis within plants and reconstituting this pathway within heterologous organisms.

His research centres on the use of in vitro biochemical analysis and chemical biology to understand the enzymes involved in starch and other carbohydrate metabolism within plant systems.

Starch is one of the most abundant biopolymers and constitutes the main sources of energy for mankind, as well as having industrial and economic impact as both bulk commodities and added value products.

Mike's work complements collaborative synthetic biology (Zeeman lab, ETH, Zurich) and mathematical computational modelling (Ebenhoeh lab, Heinrich Heine University, Dusseldorf) projects working towards a better understanding and therefore manipulation of starch and alpha-glucan structure.

Recent Publications

Rugen M. D., Rejzek M., Naested H., Svensson B., Field R. A. (2018)

High-Throughput In Vitro Screening for Inhibitors of Cereal a-Glucosidase.

Publisher’s version: 10.1007/978-1-4939-7874-8_9

Rugen M. D., Andriotis V. M. E., Field R. A. (2017)

Small-Molecule Probes of Plant Glycopolymer Metabolism

Publisher’s version: 10.1016/B978-0-12-409547- 2.12657-5

Andriotis V. M., Rejzek M., Barclay E., Rugen M. D., Field R. A., Smith A. M. (2016)

Cell wall degradation is required for normal starch mobilisation in barley endosperm.

Scientific reports 6 p33215

Publisher’s version: 10.1038/srep33215

Andriotis V. M. E., Rejzek M., Rugen M. D., Svensson B., Smith A. M., Field R. A. (2016)

Iminosugar inhibitors of carbohydrate-active enzymes that underpin cereal grain germination and endosperm metabolism.

Biochemical Society Transactions 44 p159-165

Publisher’s version: 10.1042/BST20150222

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