Prof Mike Merrick

Emeritus Fellow
Molecular Microbiology

Throughout my research career my interests have focussed on bacterial nitrogen metabolism and the ways in which bacteria control all aspects of that metabolism in response to the availability of fixed nitrogen (for reviews see: Arcondeguy et al, 2001; Huergo et al, 2013).

For many years the primary focus of research in my lab concerned the biology of the ubiquitous ammonium transport (Amt) proteins and of the signal transduction proteins of the PII family. Ammonium transport (Amt) proteins are found in eubacteria, archaebacteria, fungi, plants, and lower animals. Members of the Amt family are also present in higher animals including humans where their homologues are the Rhesus (Rh) proteins. The PII proteins are one of the most widely distributed families of signal transduction proteins in nature. They are pivotal players in the control of nitrogen metabolism and are found in bacteria, archaea and in the plastids of plants.  A detailed discussion of these topics can be found on my personal web pages.

JIC-led studentship programme receives £12.5M investment for next generation of scientists

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Selected Publications

Radchenko M. V., Thornton J., Merrick M. (2013)

PII signal transduction proteins are ATPases whose activity is regulated by 2-oxoglutarate.

Proceedings of the National Academy of Sciences of the United States of America 110 p12948-12953

Publisher’s version: 10.1073/pnas.1304386110

Radchenko M. V., Thornton J., Merrick M. (2010)

Control of AmtB-GlnK complex formation by intracellular levels of ATP, ADP and 2-Oxoglutarate

Journal of Biological Chemistry 285 p31037-31045

Publisher’s version: 10.1074/jbc.M110.153908

Recent Publications

Merrick M. (2015)

Post-translational modification of PII signal transduction proteins

Frontiers in Microbiology 5 p763

Publisher’s version: 10.3389/fmicb.2014.00763

Wang J., Fulford T., Shao Q., Javelle A., Yang H., Zhu W., Merrick M. (2013)

Ammonium transport proteins with changes in one of the conserved pore histidines have different performance in ammonia and methylamine conduction.

PLoS ONE 8 pe62745

Publisher’s version: 10.1371/journal.pone.0062745

Huergo L. F., Chandra G., Merrick M. (2013)

P(II) signal transduction proteins: nitrogen regulation and beyond.

FEMS Microbiology Reviews 37 p251-283

Publisher’s version: 10.1111/j.1574-6976.2012.00351.x

Huergo L. F., Pedrosa F. O., Muller-Santos M., Chubatsu L. S., Monteiro R. A., Merrick M., Souza E. M. (2012)

PII signal transduction proteins: pivotal players in post-translational control of nitrogenase activity.

Microbiology 158 p176-190

Publisher’s version: 10.1099/mic.0.049783-0

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