Prof Mervyn Bibb
The acquisition of antibiotic resistance, and frequently of multi-drug resistance, by a broad range of bacterial pathogens has led to an urgent need for new clinically useful antibiotics. Mervyn Bibb’s research focuses on understanding antibiotic production and its regulation in actinomycetes, the major source of clinically useful antibiotics. The resulting knowledge is used not only to understand how these complex molecules are made, but also to engineer the producing organisms using synthetic biology to make potentially improved derivatives. Genome sequencing has revealed that actinomycetes have the potential to produce many more natural products than previously thought, many of which are likely to possess anti-microbial activity; work in his group also focuses on the activation of these silent biosynthetic gene clusters, which has led to the discovery of novel compounds with anti-bacterial activity. Work in his group led to the formation of two JIC spin-out companies, Novacta Biosystems and Procarta Biosystems, of which he is co-founder.
A relA-dependent regulatory cascade for auto-induction of microbisporicin production in Microbispora corallina
Publisher’s version: 10.1111/mmi.13046
Use of the Meganuclease I-SceI of Saccharomyces cerevisiae to select for gene deletions in actinomycetes.
Scientific Reports 4 p7100
Publisher’s version: 10.1038/srep07100
Antimicrobial Agents and Chemotherapy 58 p04272-14
Publisher’s version: 10.1128/AAC.04272-14
The relationship between glycopeptide production and resistance in the actinomycete Nonomuraea sp. ATCC 39727.
Antimicrobial Agents and Chemotherapy 58 p5191-5201
Publisher’s version: 10.1128/AAC.02626-14
Heterologous expression of natural product biosynthetic gene clusters in Streptomyces coelicolor: from genome mining to manipulation of biosynthetic pathways.
Journal of Industrial Microbiology & Biotechnology 41 (2) p425-31
Publisher’s version: 10.1007/s10295-013-1348-5
- Dr Govind Chandra Senior Scientist
- Dr Juan-Pablo Gomez-Escribano Research Assistant
- Dr Neil Holmes Visiting Worker
- Dr David Widdick Postdoctoral Scientist
- Dr Elisa Binda Visiting Worker
Heatley Medal and Prize, 2013
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