Directory

Prof Mervyn Bibb

Project Leader
Molecular Microbiology

The acquisition of antibiotic resistance, and frequently of multi-drug resistance, by a broad range of bacterial pathogens has led to an urgent need for new clinically useful antibiotics. Mervyn Bibb’s research focuses on understanding antibiotic production and its regulation in actinomycetes, the major source of clinically useful antibiotics. The resulting knowledge is used not only to understand how these complex molecules are made, but also to engineer the producing organisms using synthetic biology to make potentially improved derivatives.  Genome sequencing has revealed that actinomycetes have the potential to produce many more natural products than previously thought, many of which are likely to possess anti-microbial activity; work in his group also focuses on the activation of these silent biosynthetic gene clusters, which has led to the discovery of novel compounds with anti-bacterial activity. Work in his group led to the formation of two JIC spin-out companies, Novacta Biosystems and Procarta Biosystems, of which he is co-founder.

Ants and antibiotics

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New way to improve antibiotic production

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JIC research describes new techniques to study protein-DNA interactions

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Q&A with Professor Mervyn Bibb

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Recent Publications

Fernandez-Martinez L. T., Gomez-Escribano J. P., Bibb M. J. (2015)

A relA-dependent regulatory cascade for auto-induction of microbisporicin production in Microbispora corallina

Molecular Microbiology

Publisher’s version: 10.1111/mmi.13046

Fernandez-Martinez L. T., Bibb M. J. (2014)

Use of the Meganuclease I-SceI of Saccharomyces cerevisiae to select for gene deletions in actinomycetes.

Scientific Reports 4 p7100

Publisher’s version: 10.1038/srep07100

Fernandez-Martinez L. T., Borsetto C., Gomez-Escribano J. P., Bibb M. J., Al-Bassam M. M., Chandra G., Bibb M. J. (2014)

New insights into chloramphenicol biosynthesis in Streptomyces venezuelae ATCC 10712

Antimicrobial Agents and Chemotherapy 58 p04272-14

Publisher’s version: 10.1128/AAC.04272-14

Marcone G. L., Binda E., Carrano L., Bibb M., Marinelli F. (2014)

The relationship between glycopeptide production and resistance in the actinomycete Nonomuraea sp. ATCC 39727.

Antimicrobial Agents and Chemotherapy 58 p5191-5201

Publisher’s version: 10.1128/AAC.02626-14

Gomez-Escribano J. P., Bibb M. J. (2014)

Heterologous expression of natural product biosynthetic gene clusters in Streptomyces coelicolor: from genome mining to manipulation of biosynthetic pathways.

Journal of Industrial Microbiology & Biotechnology 41 (2) p425-31

Publisher’s version: 10.1007/s10295-013-1348-5

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Mervyn Bibb

  • Dr Govind Chandra Senior Scientist
  • Dr Juan-Pablo Gomez-Escribano Research Assistant
  • Dr Neil Holmes Postdoctoral Scientist
  • Dr David Widdick Postdoctoral Scientist
  • Anyarat Thanapipatsiri Postgraduate Student
  • Dr Elisa Binda Visiting Worker

Awards

Fellow of the Royal Society, 2013

Heatley Medal and Prize, 2013

Media

For media enquiries, please contact the JIC communications team 01603 450962, jic.communications@jic.ac.uk

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