Dr David Lawson

Senior Scientist
Biological Chemistry

I manage the Protein X-ray Crystallography Platform at JIC with the assistance of Clare Stevenson.

X-ray crystallography is essentially a form of very high resolution microscopy, enabling us to visualize protein structures at the atomic level. As a result, we can determine how proteins interact with other molecules (e.g. substrates, drugs or DNA), how they undergo structural changes, and how they are structurally-related to other known proteins. These observations enhance our understanding of protein function (e.g. in catalysis or gene regulation) and protein evolution, and may assist in the design of novel therapeutic agents that target a particular protein, or could inform the rational engineering of an enzyme for a specific purpose.

The Platform provides facilities for growing protein crystals and collecting preliminary X-ray data, and can assist, advise and offer training on any aspect of protein crystallography. We also coordinate access to high intensity X-rays at the Diamond Light Source (Oxfordshire) for researchers across the Norwich Research Park. 

Recent Publications

Kuhaudomlarp S., Walpole S., Stevenson C. E. M., Nepogodiev S. A., Lawson D. M., Angulo J., Field R. A. (2018)

Unravelling the Specificity of Laminaribiose Phosphorylase from Paenibacillus sp. YM-1 towards Donor Substrates Glucose/Mannose 1-Phosphate by Using X-ray Crystallography and Saturation Transfer Difference NMR Spectroscopy.

Chembiochem : a European journal of chemical biology

Publisher’s version: 10.1002/cbic.201800260

Stavrinides A., Tatsis E., Caputi L., Stevenson C., Lawson D., O'Connor S. E., Dang T. T. T. (2018)

Discovery of a short chain dehydrogenase from Catharanthus roseus that produces a novel monoterpene indole alkaloid

ChembioChem XX pXX

Publisher’s version: XXXXXXX

Buttner M. J., Schäfer M., Lawson D. M., Maxwell A. (2018)

Structural insights into simocyclinone as an antibiotic, effector ligand and substrate.

FEMS Microbiology Reviews 42 p100112

Publisher’s version: 10.1093/femsre/fux055

O'Neill E. C., Pergolizzi G., Stevenson C. E. M., Lawson D. M., Nepogodiev S. A., Field R. A. (2017)

Cellodextrin phosphorylase from Ruminiclostridium thermocellum: X-ray crystal structure and substrate specificity analysis

Carbohydrate Research 451 p118-132

Publisher’s version: 10.1016/j.carres.2017.07.005

Ghilarov D., Serebryakova M., Stevenson C. E. M., Hearnshaw S. J., Volkov D. S., Maxwell A., Lawson D. M., Severinov K. (2017)

The Origins of Specificity in the Microcin-Processing Protease TldD/E.

Structure 25 p1549-1561.e5

Publisher’s version: 10.1016/j.str.2017.08.006

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