Prof Dale Sanders
My research focusses on how plant cells respond to changes in their environment and how they store the nutrients they acquire. In particular, my laboratory works on how transport of chemical elements across cell membranes in plants is integrated with cellular signalling and nutritional status.
Plant transport systems have key roles in the control of crucial crop traits such as nutritional value of foods, seed germination, the response to drought conditions and how plants cope with toxic compounds in the soil.
Zinc deficiency is thought to impact on 30% of the world’s population, due in part, to the near absence of the metal in cereal endosperm. Work in my laboratory on the characterisation of novel cation diffusion facilitators in Arabidopsis and cereals involved in the transport of zinc is identifying a bio-fortification strategy to enrich the endosperm in this heavy metal.
Nutrient accumulation in plant vacuoles is energised by a proton-motive force established by two types of phosphohydrolase: an ATPase and an inorganic pyrophosphatase. We are unravelling the distinct roles in nutrient acquisition played by these two classes of enzyme.
I have authored over 140 scientific papers, many of which have been highly cited and in 2001 was elected a Fellow of the Royal Society and co-awarded the European Science Prize of the Körber Foundation.
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Nature 497 (7447) p60-6
Publisher’s version: 10.1038/nature11909
Journal of Biological Chemistry 287 (5) p3185-96
Publisher’s version: 10.1074/jbc.M111.305649
Annual Review of Plant Biology 61 p593-620
Publisher’s version: 10.1146/annurev-arplant-070109-104628
Plant Journal 56 p665-677
Plant Journal 56 p146-156
Biofortification of wheat grain with iron and zinc: integrating novel genomic resources and knowledge from model crops
Frontiers in Plant Science 5 (53)
Publisher’s version: 10.3389/fpls.2014.00053
Annual Reviews in Plant Biology 61 p593-620
Plant Physiology 145 p192-203
Arabidopsis thaliana cyclic nucleotide gated channel 3 forms a non-selective ion transporter involved in germination and cation transport
Journal of Experimental Botany 57 p791-800
Transcriptional analysis of calcium-dependent and calcuim-independent signalling pathways induced by oligogalacturonides
Journal of Experimental Botany 57 p2847-2865
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