Sunday 20th July
15:00-17:00 |
Registration |
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17:00 |
Organisers |
Opening remarks |
Opening session (Chair – Yves Pommier) |
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17:10 |
Patrick Forterre |
Origin and evolution of DNA topoisomerases |
17:50 |
James Champoux |
Recent studies on the repair of topoisomerase I-DNA covalent complexes |
18:30 |
Jorge Schvartzman |
Interplay of DNA superco8iling and catenation during the segregatrion of sister duplexes |
18:50 |
Reception (sponsored by Astrazeneca) and poster session |
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Monday 21st July
08:50 |
Organisers & Director |
Introduction & welcome |
DNA Topology (Chair – David Hooper) |
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09:00 |
Andrzej Stasiak |
Effect of DNA supercoiling on DNA knotting |
09:40 |
Lynn Zechiedrich |
DNA twisting denatures DNA, flips bases, and triggers P-DNA to preserve B-form DNA |
10:20 |
Coffee/tea |
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10:50 |
Vincent Croquette |
Torque versus twist - dependence upon salt conditions in magnetic tweezers experiments (The British Biophysical Society Lecture) |
11:30 |
Zev Bryant |
Single molecule mechanics of DNA and topoisomerases |
12:10 |
Michael Thompson |
Energy concepts for topoisomerases: new insights from elastic rod theory |
12:30 |
Jonathan Fogg |
Dissecting the supercoiling dependence of topoisomerases using minicircle DNA |
12:50 |
Lunch/coffee & posters |
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Topoisomerase structure & mechanism (Chair – James Berger) |
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14:00 |
Alfonso Mondragon |
Structural studies of type I topoisomerases |
14:40 |
Dagmar Klostermeier |
Mechanistic studies on gyrase and reverse gyrase |
15:00 |
Stewart Shuman |
Topo I and DNA ligase: birds of a feather? |
15:40 |
Tea/coffee |
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16:10 |
PLENARY: Nucleic acids award lecture – introduced by Mike Gait, RSC Nucleic Acids Group (Chair – Tony Maxwell) |
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16:20 |
Martin Gellert |
Twists and turns of DNA gyrase |
17:20 |
Close |
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19:30 |
Reception/dinner in Norwich sponsored by Inspiralis and Norwich City Council |
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Tuesday 22nd July
Topoisomerase structure & mechanism cont’d (Chair – James Berger) |
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08:40 |
Tao Hsieh |
Monitoring the conformational dynamics in topoisomerase II |
09:20 |
Neil Osheroff |
The DNA cleavage reaction of topoisomerase II |
10:00 |
Nicole Baker |
Solution studies of DNA bound Gyrase |
10:20 |
Coffee/tea |
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10:50 |
Manlio Palumbo |
Metal ion effects in topoisomerase structure and function |
11:30 |
Alexander Vologodskii |
Simplification of DNA topology by type II DNA topoisomerases. A new development |
12:10 |
Nynke Dekker |
Single-Molecule Studies of Supercoil Dynamics and Removal |
12:50 |
Lunch/coffee & posters |
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14:00 |
Topoisomerases in Chemotherapy (Chair – Andrzej Stasiak) |
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14:00 |
Karl Drlica |
Fluoroquinolone action and resistance |
14:40 |
Valakunja Nagaraja |
New approaches to inhibit DNA topoisomerases from mycobacteria |
15:00 |
David Hooper |
Resistance to bacterial topoisomerase poisons |
15:40 |
Tea/coffee |
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16:10 |
Yuk-Ching Tse-Dinh |
Bacterial topoisomerase I as a target for discovery of antibacterial compounds |
16:50 |
Mary-Ann Bjornsti |
Cellular responses to DNA topoisomerase I-induced DNA damage |
17:30 |
Close |
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Evening |
Free evening |
Optional: Woodforde's Brewery trip (sign up) |
Wednesday 23rd July
09:00 |
Leroy Liu |
Ubiquitin and ubiquitin-like proteins in processing/repair of topoisomerase cleavage complexes |
09:40 |
Yves Pommier |
Mitochondrial topoisomerases |
10:20 |
Coffee/tea |
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10:50 |
Topoisomerases in vivo (Chair – Patrick Forterre) |
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10:50 |
Charles Dorman |
Bacterial DNA topology and infectious disease |
11:30 |
John Nitiss |
Cell killing by Top2:DNA covalent complexes does not require enzyme mediated double strand breaks |
11:50 |
Ian Hickson |
The RecQ helicase/topoisomerase III complex as a DNA structure-specific dissolvasome |
12:30 |
Lunch/coffee posters |
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14:00 |
Ignacio Bermudez |
Genome-wide analyses of DNA topology and topoisomerase function |
14:40 |
Caroline Austin |
Human topoisomerase IIa DNA binding sites isolated by chromatin immunoprecipitation |
15:00 |
Keiko Sugimoto |
Functional role of DNA topoisomerase VI in plant development |
15:40 |
Tea/coffee |
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PLENARY (Chair – Andy Bates) |
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16:10 |
James Berger |
(Un)Tying the knot: how structure helped disentangle the biochemistry of type II topoisomerases, and vice versa |
17:10 |
Close |
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19:30 |
Conference dinner; Sprowston Manor Hotel and Country Club |
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Thursday 24th July
Depart |
Programme committee: