Publications

2009

Edwards M. J., Flatman R. H., Mitchenall L. A., Stevenson C. E., Le T. B., Clarke T. A., McKay A. R., Fiedler H. P., Buttner M. J., Lawson D. M., Maxwell A. (2009). A crystal structure of the bifunctional antibiotic simocyclinone D8, bound to DNA gyrase. Science 326 (5958), 1415-8.
Abstract; Full text

Edwards M. J., Flatman R. H., Mitchenall L. A., Stevenson C. E., Maxwell A., Lawson D. M. (2009). Crystallization and preliminary X-ray analysis of a complex formed between the antibiotic simocyclinone D8 and the DNA breakage-reunion domain of Escherichia coli DNA gyrase. Acta Crystallographica Section F: Structural Biology & Crystallization Communications 65 (Pt 8) 846-8.

Evans-Roberts K., Maxwell A. (2009). DNA topoisomerases Ecosal-Escherichia coli and Salmonella: Cellular and Molecular Biology. ASM Press, Washington, D.C. (4.4.9) Electronic only: http://www.ecosal.org

Le T. B., Fiedler H. P., den Hengst C. D., Ahn S. K., Maxwell A., Buttner M. J. (2009). Coupling of the biosynthesis and export of the DNA gyrase inhibitor simocyclinone in Streptomyces antibioticus. Molecular Microbiology 72 (6) 1462-1474.

Stuchinskaya, T., Mitchenall, L. A., Schoeffler, A. J., Corbett, K. D., Berger, J. M., Bates, A. D. and Maxwell, A. (2009). How do type II topoisomerases use ATP hydrolysis to simplify DNA topology beyond equilibrium? Investigating the relaxation reaction of nonsupercoiling type II topoisomerases. J Mol Biol 385, 1397-408.

2008

Anderle, C., Stieger, M., Burrell, M., Reinelt, S., Maxwell, A., Page, M. and Heide, L. (2008). Biological activities of novel gyrase inhibitors of the aminocoumarin class. Antimicrob Agents Chemother 52, 1982-90.

Hashimi, S. M., Huang, G., Maxwell, A. and Birch, R. G. (2008). DNA Gyrase from the Albicidin Producer Xanthomonas albilineans Has Multiple-Antibiotic-Resistance and Unusual Enzymatic Properties. Antimicrob Agents Chemother 52, 1382-90.

Sissi, C., Chemello, A., Vazquez, E., Mitchenall, L. A., Maxwell, A. and Palumbo, M. (2008). DNA gyrase requires DNA for effective two-site coordination of divalent metal ions: further insight into the mechanism of enzyme action. Biochemistry 47, 8538-45.

2007

Richter, S.N., Giaretta, G., Comuzzi, V., Leo, E., Mitchenall, L.A., Maxwell, A. and Palumbo, M. (2007) Hot-spot consensus of fluoroquinolone-mediated DNA cleavage by Gram-negative and Gram-positive type II DNA topoisomerases. Nucleic Acids Res., 35, 6075-85. 

Breuer, C., Stacey, N. J., West, C. E., Zhao, Y., Chory, J., Tsukaya, H., Azumi, Y., Maxwell, A., Roberts, K. and Sugimoto-Shirasu, K. (2007). BIN4, a novel component of the plant DNA topoisomerase VI complex, is required for endoreduplication in Arabidopsis. Plant Cell 19, 3655-68.

Parks, W.M., Bottrill, A.R., Pierrat, O.A., Durrant, M.C. and Maxwell, A. (2007) The action of the bacterial toxin, microcin B17, on DNA gyrase. Biochimie, 89, 500-507.

Nollmann, M., Stone, M.D., Bryant, Z., Gore, J., Crisona, N.J., Hong, S.C., Mitelheiser, S., Maxwell, A., Bustamante, C. and Cozzarelli, N.R. (2007) Multiple modes of Escherichia coli DNA gyrase activity revealed by force and torque. Nat Struct Mol Biol, 14, 264-271.

Hashimi, S.M., Wall, M.K., Smith, A.B., Maxwell, A. and Birch, R.G. (2007) The phytotoxin albicidin is a novel inhibitor of DNA gyrase. Antimicrob Agents Chemother, 51, 181-187.

Costenaro, L., Grossmann, J.G., Ebel, C. and Maxwell, A. (2007) Modular structure of the full-length DNA gyrase B subunit revealed by small-angle X-ray scattering. Structure, 15, 329-339.

Bates, A.D. and Maxwell, A. (2007) Energy Coupling in Type II Topoisomerases: Why Do They Hydrolyze ATP? Biochemistry, 46, 7929-7941.

2006

Stacey, N.J., Kuromori, T., Azumi, Y., Roberts, G.R., Breuer, C., Wada, T., Maxwell, A., Roberts, K. and Sugimoto-Shirasu, K. (2006) Arabidopsis SPO11-2 functions with SPO11-1 in meiotic recombination. Plant J., 48, 206-216.

Smith, A.B. and Maxwell, A. (2006) A strand-passage conformation of DNA gyrase is required to allow the bacterial toxin, CcdB, to access its binding site. Nucleic Acids Res, 34, 4667-4676.

Oram, M., Travers, A.A., Howells, A.J., Maxwell, A. and Pato, M.L. (2006) Dissection of the bacteriophage Mu strong gyrase site (SGS): significance of the SGS right arm in Mu biology and DNA gyrase mechanism. J Bacteriol, 188, 619-632.

Maxwell, A., Burton, N.P. and O'Hagan, N. (2006) High-throughput assays for DNA gyrase and other topoisomerases. Nucleic Acids Res, 34, e104.

Huang, Y.Y., Deng, J.Y., Gu, J., Zhang, Z.P., Maxwell, A., Bi, L.J., Chen, Y.Y., Zhou, Y.F., Yu, Z.N. and Zhang, X.E. (2006) The key DNA-binding residues in the C-terminal domain of Mycobacterium tuberculosis DNA gyrase A subunit (GyrA). Nucleic Acids Res, 34, 5650-5659.

Flatman, R.H., Eustaquio, A., Li, S.M., Heide, L. and Maxwell, A. (2006) Structure-activity relationships of aminocoumarin-type gyrase and topoisomerase IV inhibitors obtained by combinatorial biosynthesis. Antimicrob Agents Chemother, 50, 1136-1142.

Burlison, J.A., Neckers, L., Smith, A.B., Maxwell, A. and Blagg, B.S. (2006) Novobiocin: Redesigning a DNA Gyrase Inhibitor for Selective Inhibition of Hsp90. J Am Chem Soc, 128, 15529-15536.

2005

Hegde SS, Vetting MW, Roderick SL, Mitchenall LA, Maxwell A, Takiff HE, Blanchard JS (2005) A fluoroquinolone resistance protein from Mycobacterium tuberculosis that mimics DNA. Science 308, 1480-1483.

Manjunatha UH, Maxwell A, Nagaraja V (2005) A monoclonal antibody that inhibits mycobacterial DNA gyrase by a novel mechanism. Nucleic Acids Res 33, 3085-3094.

Maxwell A, Costenaro L, Mitelheiser S, Bates AD (2005) Coupling ATP hydrolysis to DNA strand passage in type IIA DNA topoisomerases. Biochem. Soc. Trans. 33, 1460-1464.

Sissi C, Marangon E, Chemello A, Noble CG, Maxwell A, Palumbo M (2005) The effects of metal ions on the structure and stability of the DNA gyrase B protein. J Mol Biol 353, 1152-1160.

Sugimoto-Shirasu K, Roberts GR, Stacey NJ, Hofte H, McCann MC, Maxwell A, Roberts K (2005) RHL1 is an essential component of the plant DNA topoisomerase VI complex and is required for ploidy-dependent cell growth. Proc. Natl. Acad. Sci. USA 102, 18736-18741.

Pierrat, O.A. and Maxwell, A. (2005) The effect of Microcin B17 on the ATPase and DNA cleavage reactions of DNA gyrase: evidence for the role of DNA strand passage in the mechanism of toxin action. Biochemistry, 44, 4204-4215.

Flatman, R.H., Howells, A.J., Heide, L., Fiedler, H.-P. and Maxwell, A. (2005) Simocyclinone D8: an inhibitor of DNA gyrase with a novel mode of action. Antimicrob Agents Chemother, 49, 1093-1100.

Edmondson, A.C., Song, D., Alvarez, L.A., Wall, M.K., Almond, D., McClellan, D.A., Maxwell, A. and Nielsen, B.L. (2005) Characterization of an Arabidopsis thaliana mitochondrial-targeted single-stranded DNA binding protein. Mol Genet Genomics, 273, 115-122.

Costenaro, L., Grossmann, J.G., Ebel, C. and Maxwell, A. (2005) Small-angle X-ray scattering reveals the solution structure of the full-length DNA gyrase A subunit. Structure, 13, 287-296.

Bates, A.D. and Maxwell, A. (2005) DNA topology. Oxford University Press, Oxford.