Steph Bornemann Lab Home Page
Our current lines of enquiry are polyglucan
biosynthesis in microbes and plants, and symbiosis
signalling in plants. We are a multidisciplinary group that studies enzymes at the atomic level using biochemical and biophysical methods along with complementary molecular biology approaches to address physiological function. Our work is framed within the context of food security (nitrogen utilisation and carbon storage in plants) and human health (novel targets for antibiotics). Enzymes that have been studied previously include cupins
, such as oxalate-degading enzymes
, and chorismate synthase
that are involved in plant and microbial responses to biotic and abiotic stress or are targets for antibiotics and herbicides.
Mycobacterium tuberculosis maltosyltransferase GlgE, a genetically validated anti-tuberculosis target, is negatively regulated by Ser/Thr phosphorylation
Flux through Trehalose Synthase Flows from Trehalose to the Alpha Anomer of Maltose in Mycobacteria
All opportunities at the John Innes Centre
Please email me if you want to bring your own fellowship or funding.