Steph Bornemann Lab Home Page
Our current lines of enquiry are polyglucan
biosynthesis in microbes and plants, and symbiosis
signalling in plants. We are a multidisciplinary group that studies enzymes at the atomic level using biochemical and biophysical methods along with complementary molecular biology approaches to address physiological function. Our work is framed within the context of food security (nitrogen utilisation and carbon storage in plants) and human health (novel targets for antibiotics). Enzymes that have been studied previously include cupins
, such as oxalate-degading enzymes
, and chorismate synthase
that are involved in plant and microbial responses to biotic and abiotic stress or are targets for antibiotics and herbicides.
Structural insight into how Streptomyces coelicolor maltosyl transferase GlgE binds α-maltose 1-phosphate and forms a maltosyl-enzyme intermediate
CCaMK is negatively and positively regulated by calcium, providing a novel mechanism for decoding calcium responses
Discrimination of large maltooligosaccharides from isobaric dextran and pullulan using ion mobility mass spectrometry
Sugar-coated sensor chip and nanoparticle surfaces for the in vitro enzymatic synthesis of starch-like materials
All opportunities at the John Innes Centre
Please email me if you want to bring your own fellowship or funding.