Publications
2011
GLYCOBIOLOGY: Challenging reaction equilibria. R. A. Field. Nature Chemical Biology, 2011, 7(10), 658-659.
Synthesis of apiose-containing oligosaccharide fragments of the plant cell wall: fragments of rhamnogalacturonan-II side chains A and B, and apiogalacturonan. S. A. Nepogodiev, M. Fais, D. L. Hughes, R. A. Field. Organic and Biomolecular Chemistry, 2011, 9, 6670-84.
Surface plasmon resonance imaging of glycoarrays identifies novel andunnatural carbohydrate-based ligands for potential ricin sensor development. M. Fais, R. Karamanska, S. Allman, S. A. Fairhurst, P. Innocenti, A. J. Fairbank, T. J. Donohoe, B. G. Davis, D. A. Russell, R. A. Field, Chemical Science, 2011, 2, 1952-1959.
The saponins – polar isoprenoids with important and diverse biological activities. A. Osbourn, R. J. M. Goss, R. A. Field, Nat. Prod. Rep., 2011, 28, 1261-1268.
Glycoclusters presenting lactose on calix[4]arene cores displaytrypanocidal activity. E. Galante, C. Geraci, S. Sciuto, V. L. Campo, I. Carvalho, R. Sesti-Costa, P. M. M. Guedes, J. S. Silva, L. Hill, S. A. Nepogodiev, R. A. Field, Tetrahedron, 2011, 67, 5902-5912.
Synthesis of fluorescently labelled rhamnosides: probes for the evaluation of rhamnogalacturonan II biosynthetic enzymes. E. Prifti, S. Goetz, S. A. Nepogodiev, R. A. Field, Carbohydrate Research, 2011, 346, 1617–1621.Probing the acceptor substrate binding site of Trypanosoma cruzi trans-sialidase with systematically modified substrates and glycoside libraries. J. A. Harrison, K. P. Kartha, E. J. Fournier, T. L. Lowary, C. Malet, U. J. Nilsson, O. Hindsgaul, S. Schenkman, J. H. Naismith, R. A. Field, Organic and Biomolecular Chemistry, 2011, 9 1653-1660.
An expression system for screening of proteins for glycan and protein interactions. D. M. Otto, M. A. Campanero-Rhodes, R. Karamanska, A. K. Powell, N. Bovin, J. E. Turnbull, R. A. Field, J. Blackburn, T. Feizi, P. R. Crocker, Analytical Biochemistry, 2011, 411, 261-270.
The role of {alpha}-glucosidase in germinating barley grains. D. Stanley, M. Rejzek, H. Naested, M. Smedley, S. Otero, B. Fahy, F. Thorpe, R. J. Nash, W. Harwood, B. Svensson, K. Denyer, R. A. Field, A. M. Smith, Plant Physiology, 2011, 155, 932-943.
Chemical genetics and cereal starch metabolism: structural basis of the non-covalent and covalent inhibition of barley β-amylase. M. Rejzek, C. E. Stevenson, A. M. Southard, D. Stanley, K. Denyer, A. M. Smith, M. J. Naldrett, D. M. Lawson, R. A. Field, Molecular BioSystems, 2011, 7, 718-730.
Approaches to chemical synthesis of pectic oligosaccharides. S. A. Nepogodiev, R. A. Field, I. Damager, Annual Plant Reviews: Plant Polysaccharides, Biosynthesis and Bioengineering (Editors: Ulvskov P.) Wiley-Blackwell, Oxford, UK. 2011, Volume 41 65-89.
2010
Application of copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) ‘click chemistry’ in carbohydrate drug and neoglycopolymer synthesis. V. Aragão-Leoneti, V. L. Campo, A. S. Gomes, R. A. Field, I. Carvalho, Tetrahedron, 2010, 66, 9475-9492.
Cyclooligomerisation of azido-alkyne-functionalised sugars: synthesis of 1,6-linked cyclic pseudo-galactooligosaccharides and assessement of their sialylation by Trypanosoma cruzi trans-sialidase. V. L. Campo, I. Carvalho, C. H. T. P. Da Silva, S. Schenkman, L. Hill, S. A. Nepogodiev, R. A. Field, Chem. Sci., 2010, 1, 507-514.
Synthesis and anti-HIV activity of triterpene 3-O-galactopyranosides, analogs of glycyrrhizic acid. L. A. Baltina, Jr., L. A. Baltina, R. M. Kondratenko, O. A. Plyasunova, S. A. Nepogodiev, R. A. Field, Chemistry of Natural Compounds, 2010, 46, 576-582.
Synthesis of a ‘manno-Gb3’ analogue as a potential Shiga toxin/Verotoxin inhibitor. K. P. R. Kartha, S. W. Homans, R. A. Field, Trends Carb. Res., 2010, 2, 14-19.
Synthesis of alpha- and beta-D-glucopyranosyl triazoles by CuAAC 'click chemistry': reactant tolerance, reaction rate, product structure and glucosidase inhibitory properties. S. Dedola, D. L. Hughes, S. A. Nepogodiev, M. Rejzek, R. A. Field, Carbohydrate Research, 2010, 345 (9), 1123-34
'Click chemistry' synthesis of a library of 1,2,3-triazole-substituted galactose derivatives and their evaluation against Trypanosoma cruzi and its cell surface trans-sialidase. I. Carvalho, P. Andrade, V. L. Campo, P. M. Guedes, R. Sesti-Costa, J. S. Silva, S. Schenkman, S. Dedola, L. Hill, M. Rejzek, S. A. Nepogodiev, R. A. Field, Bioorganic & Medicinal Chemistry, 2010, 18 (7), 2412-27
Peracetylated alpha-D-glucopyranosyl fluoride and peracetylated alpha-maltosyl fluoride. S. Dedola, D. L. Hughes, R. A. Field, Acta Crystallographica, 2010, C66, o124-o127
Detection of enzyme-catalyzed polysaccharide synthesis on surfaces. C. Cle, C. Martin, R. A. Field, P. Kuzmic, S. Bornemann, Biocat. Biotrans., 2010, 28, 64-71
2009
Synthesis of starch fragments. S. A. Nepogodiev, R. A. Field, in Progress in the synthesis of complex carbohydrate chains of plant and microbial polysaccharides. N. Nifantiev Ed., Transworld Research Network, 37/661 (2), Fort P.O., Trivandrum-695 023, Kerala, India. ISBN: 978-81-7895-424-0. 2009, Chapter 6, pp 155-180
Synthesis of oligosaccharide fragments of pectic polysaccharides. S. A. Nepogodiev, I. Damager, R. A. Field, in Progress in the synthesis of complex carbohydrate chains of plant and microbial polysaccharides. N. Nifantiev Ed., Transworld Research Network, 37/661 (2), Fort P.O., Trivandrum-695 023, Kerala, India. ISBN: 978-81-7895-424-0. 2009, Chapter 2, pp33-60
A simple method of synthesis of triterpene glycosides similar to glycyrrhizic acid and their hepatoprotective activity in vitro. L. R. Mikhailova, L. A. Baltina Jr., L. A. Baltina, R. M. Kondratenko, S. A. Nepogodiev, R. A. Field, O. Kunert, M. Ch. Yin, Russ. J. Bioorg. Chem., 2009, 35, 619-627.
Synthesis of a tetrasaccharide related to the repeating unit of the O antigen from Escherichia coli K-12. B. Roy, R. A. Field, B. Mukhopadhyay, Carbohydr. Res., 2009, 344, 2311-2316
Lectin and carbohydrate microarrays: New high through-put methods for glycoprotein, carbohydrate-binding protein and carbohydrate-active enzyme analysis. M. Fais, R. Karamanska, D. A. Russell, R. A. Field, J. Cereal Sci., 2009, 50, 306-311
A survey of chemical methods for sugar-nucleotide synthesis. G. K. Wagner, T. Pesnot, R. A. Field, Nat. Prod. Rep., 2009, 26, 1172-1194.
Carbohydrate signalling molecules. R. A. Field in Plant-derived natural products: Synthesis, function and application, A. E. Osbourn and V. Lanzotti Eds, Springer, 2009.
Synthesis of prospective disaccharide ligands for Escherichia coli O157 verotoxin. C. Bernlind, S. W. Homans, R. A. Field, Tetrahedron Lett., 50th Anniversary issue, 2009, 50, 3397-3399.
A sugar aminoacid for the development of multivalent ligands for Escherichia coli 0157 verotoxin. D. Gibson, S. W. Homans, R. A. Field, Tetrahedron-Asymmetry, George Fleet special issue, 2009, 20, 730-732.
Characterization of WbpB, WbpE, and WbpD, and reconstitution of a pathway for the biosynthesis of UDP-2,3-diacetamido-2,3-dideoxy-D-mannuronic acid in Pseudomonas aeruginosa. E. L. Westman, D. J. McNally, A. Charchoglyan, D. Brewer, R. A. Field, J. S. Lam, J. Biol. Chem., 2009, 284, 11854-11862
Chemical genomics identifies compounds affecting Xenopus laevis pigment cell development. M L. Tomlinson, M. Fidock, M. Rejzek, R. A. Field, G. N. Wheeler, Molecular Biosystems, 2009, 5, 376-384.
Chemical synthesis of uridine 5’-diphospho 2,3-diacetamido-2,3-dideoxy-D-glucuronic acid (UDP-a-D-Glc-2,3-diNAcA), a key intermediate in cell surface O antigen polysaccharide biosynthesis in the human respiratory pathogens Bordetella pertussis and Pseudomonas aeruginosa. M. Rejzek, V. Sri Kannathasan, C. Wing, A. Preston, E. L. Westman, J. S. Lam, J. H. Naismith, D. J. Maskell, R. A. Field, Org. Biomol. Chem., 2009, 7, 1203-1210.
Sugar nucleotide recognition by Klebsiella pneumoniae UDP-galactopyranose mutase: fluorinated substrates, kinetics and equilibria. J. C. Errey, M. C. Mann, S. A. Fairhurst, L. Hill, M. R. McNeil, J. H. Naismith, J. M. Percy, C. Whitfield, R. A. Field, Org. Biomol. Chem., 2009, 7, 1009-1016.
Developing an asymmetric, stereodivergent route to selected 6-deoxy-6-fluoro-hexoses. A. Caravano, R. A. Field, J. M. Percy, G. Rinaudo, R. Roig, K. Singh, Org. Biomol. Chem., 2009, 7, 996-1008.
A chemical genetic approach identifies matrix metalloproteinases as playing an essential and specific role in Xenopus melanophore migration. M. L. Tomlinson, P. Guan, R. J. Morris, M. Fidock, M. Rejzek, R. A. Field and G. N. Wheeler, Chemistry & Biology, 2009, 16, 93-104.
Bacterial detection using carbohydrate-functionalised CdS quantum dots: A model study exploiting E. coli recognition of mannosides. B. Mukhopadhyay, M. B. Martins, R. Karamanska, D. A. Russell, R. A. Field, Tetrahedron Lett., 2009, 50, 886-889.
